Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys

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31 Scopus citations


The potential of dopaminergic treatments to improve upper limb motor movements was tested in 7 aged rhesus monkeys using L-3,4-dihydroxyphenylalanine (L-dopa) or the selective dopamine uptake inhibitor1-2(bis[4-fluorophenyl]methoxy]ethyl)-4-(3-phenylpropyl) piperazine hydrochloride (GBR-12909). Six young monkeys were studied for comparison. L-Dopa or GBR-12909 improved upper limb motor performance by up to 40% in the aged animals. At this point their performance was comparable to that of young adults. Dopaminergic therapy could be useful in elderly humans experiencing declines in upper limb motor functions.

Original languageEnglish
Pages (from-to)250-253
Number of pages4
JournalAnnals of Neurology
Issue number2
StatePublished - 2000

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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