Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Howard P. Glauert, Julia A. Weeks

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalToxicology Letters
Volume48
Issue number3
DOIs
StatePublished - Sep 1989

Bibliographical note

Funding Information:
We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.

Keywords

  • 1,2-Dimethylhydrazine
  • Adenocarcinomas
  • Colon carcinogenesis
  • Fischer-344 rats

ASJC Scopus subject areas

  • Toxicology

Fingerprint

Dive into the research topics of 'Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine'. Together they form a unique fingerprint.

Cite this