Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Howard P. Glauert; Julia A. Weeks

doi:10.1016/0378-4274(89)90055-6

Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Howard P. Glauert, Julia A. Weeks

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

Original language	English
Pages (from-to)	283-287
Number of pages	5
Journal	Toxicology Letters
Volume	48
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(89)90055-6
State	Published - Sep 1989

Bibliographical note

Funding Information:
We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.

Keywords

1,2-Dimethylhydrazine
Adenocarcinomas
Colon carcinogenesis
Fischer-344 rats

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(89)90055-6

Cite this

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title = "Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine",

abstract = "The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.",

keywords = "1,2-Dimethylhydrazine, Adenocarcinomas, Colon carcinogenesis, Fischer-344 rats",

author = "Glauert, {Howard P.} and Weeks, {Julia A.}",

note = "Funding Information: We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.",

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AU - Glauert, Howard P.

AU - Weeks, Julia A.

N1 - Funding Information: We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.

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N2 - The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

AB - The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.

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KW - Adenocarcinomas

KW - Colon carcinogenesis

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Dose- and time-response of colon carcinogenesis in Fischer-344 rats after a single dose of 1,2-dimethylhydrazine

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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