The purpose of this experiment was to examine the development of colon tumors after the injection of a single dose of 1,2-dimethylhydrazine (DMH) in rats. Male Fischer-344 rats were injected with 0, 10, 30, 100 or 200 mg/kg of DMH dihydrochloride. No tumors were seen after 3 or 5 months at any dose, but were seen after 7 or 9 months. At 9 months, tumors were induced in a dose-dependent manner, with 64.7% of rats receiving the 200 mg/kg dose developing tumors. This study shows that a high incidence of colon tumors can be induced by a single dose of DMH after a 9-month latency period.
|Number of pages||5|
|State||Published - Sep 1989|
Bibliographical noteFunding Information:
We thank Richard Thackcr and Wendy Greenwell for technical assistance. This work was supported by grants from the American Institute for Cancer Research (87B45) and the University of Kentucky Graduate School, Kentucky Agricultural Experiment Station journal article number 88-9-188.
- Colon carcinogenesis
- Fischer-344 rats
ASJC Scopus subject areas