Dose-related effects of fentanyl on autonomic and behavioral responses in performance horses

Steven G. Kamerling, David J. DeQuick, Timothy J. Weckman, Thomas Tobin

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

1. 1. The dose-related effects of intravenously administered fentanyl (0.010, 0.005, 0.0025 mg/kg) and saline were studied in mature performance horses using a rigorous experimental protocol. 2. 2. Fentanyl produced a dose-related prolongation of the skin twitch reflex latency but did not increase the hoof withdrawal reflex latency. 3. 3. Dose related increases in stepping frequency, cardiac and respiratory rates were observed following fentanyl, while changes in rectal temperature and pupil area were not. 4. 4. These data indicate that fentanyl, a prototypic mu-agonist, produces a syndrome characterized by analgesia, locomotor and sympathetic stimulation in the horse.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalVascular Pharmacology
Volume16
Issue number3
DOIs
StatePublished - 1985

Bibliographical note

Funding Information:
Supported by a Grant entitled "Masking by Phenyl-butazone in Equine Drug Testing: An Analysis", from the Kentucky Equine Drug Research Council of the Kentucky State Racing Commission. *All correspondence should be addressed to Dr Tobin.

Funding

Supported by a Grant entitled "Masking by Phenyl-butazone in Equine Drug Testing: An Analysis", from the Kentucky Equine Drug Research Council of the Kentucky State Racing Commission. *All correspondence should be addressed to Dr Tobin.

FundersFunder number
Equine Drug Research Council of the Kentucky Horse Racing Commission
Kentucky State Racing Commission

    ASJC Scopus subject areas

    • Pharmacology

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