Abstract
1. 1. The dose-related effects of intravenously administered fentanyl (0.010, 0.005, 0.0025 mg/kg) and saline were studied in mature performance horses using a rigorous experimental protocol. 2. 2. Fentanyl produced a dose-related prolongation of the skin twitch reflex latency but did not increase the hoof withdrawal reflex latency. 3. 3. Dose related increases in stepping frequency, cardiac and respiratory rates were observed following fentanyl, while changes in rectal temperature and pupil area were not. 4. 4. These data indicate that fentanyl, a prototypic mu-agonist, produces a syndrome characterized by analgesia, locomotor and sympathetic stimulation in the horse.
Original language | English |
---|---|
Pages (from-to) | 253-258 |
Number of pages | 6 |
Journal | Vascular Pharmacology |
Volume | 16 |
Issue number | 3 |
DOIs | |
State | Published - 1985 |
Bibliographical note
Funding Information:Supported by a Grant entitled "Masking by Phenyl-butazone in Equine Drug Testing: An Analysis", from the Kentucky Equine Drug Research Council of the Kentucky State Racing Commission. *All correspondence should be addressed to Dr Tobin.
Funding
Supported by a Grant entitled "Masking by Phenyl-butazone in Equine Drug Testing: An Analysis", from the Kentucky Equine Drug Research Council of the Kentucky State Racing Commission. *All correspondence should be addressed to Dr Tobin.
Funders | Funder number |
---|---|
Equine Drug Research Council of the Kentucky Horse Racing Commission | |
Kentucky State Racing Commission |
ASJC Scopus subject areas
- Pharmacology