Dose-response effects of peripheral nerve stimulation and motor training in stroke: Preliminary data

Emily Salyers, Cheryl Carrico, K. C. Chelette, Laurie Nichols, Cameron Henzman, Lumy Sawaki

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Stroke is one of the most devastating and prevalent diseases. However, efforts to limit tissue damage in acute stroke have met with only minimal success. Therefore, it is of paramount importance to establish effective therapies for use during long-term stages of recovery. Such therapy can capitalize on neuroplastic change (brain reorganization), which has been associated with recovery of function after brain lesions. Intensive, repetitive motor training is a therapeutic intervention that has been shown to support neuroplastic change and improve motor performance after stroke. Likewise, sensory input in the form of peripheral nerve stimulation (PNS) has been shown to upregulate neuroplasticity and improve motor performance after stroke. However, no studies have evaluated how pairing intensive motor training with various PNS intensities and times may affect motor performance, particularly for subjects with severe upper extremity (UE) hemiparesis after stroke. Here, we describe our ongoing study of whether various intensities and times of delivery of PNS relative to motor training will yield differential effects on UE motor function in subjects with chronic, severe motor deficit after stroke. Our results will facilitate development of a dose-response model for PNS paired with intensive, repetitive motor training, which will help optimize this combinatory intervention for stroke survivors with highest need.

Original languageEnglish
Title of host publication2014 IEEE 16th International Conference on e-Health Networking, Applications and Services, Healthcom 2014
Pages7-11
Number of pages5
ISBN (Electronic)9781479966448
DOIs
StatePublished - 2014
Event2014 16th IEEE International Conference on e-Health Networking, Applications and Services, Healthcom 2014 - Natal, Brazil
Duration: Oct 15 2014Oct 18 2014

Publication series

Name2014 IEEE 16th International Conference on e-Health Networking, Applications and Services, Healthcom 2014

Conference

Conference2014 16th IEEE International Conference on e-Health Networking, Applications and Services, Healthcom 2014
Country/TerritoryBrazil
CityNatal
Period10/15/1410/18/14

Keywords

  • motor function
  • neuromodulation
  • neuroplasticity
  • robotassisted
  • somatosensory

ASJC Scopus subject areas

  • Health Information Management
  • Computer Networks and Communications
  • Health Informatics

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