Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations

Sheng Tong, Fan Yuan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Angiogenesis involves interactions among various molecules and cells. To understand the complexity of interactions, we developed a mathematical model to numerically simulate angiogenesis induced by basic fibroblast growth factor (bFGF) in the corneal pocket assay. The model considered interstitial transport of bFGF, cellular uptake of bFGF, and dynamics of vessel growth. The model was validated by comparing simulated vascular networks, induced by bFGF at three different doses: 5 ng, 15 ng, and 50 ng, with experimental data obtained in the first part of the study, in terms of migration distance of vascular network, total vessel length, and number of vessels. The model was also used to simulate growth dynamics of vascular networks as well as spatial and temporal distribution of bFGF, which could not be measured experimentally. Taken together, results of the study suggested that the coupling between diffusion and cellular uptake of bFGF was critical for determining structures of vascular networks and that the mathematical model was appropriate for simulation of angiogenesis in the cornea.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalMicrovascular Research
Volume75
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Diffusion
  • Mathematical modeling
  • Vascular density
  • Vascular network

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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