Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers

George C. Brainard; Alfred J. Lewy; Michael Menaker; Richard H. Fredrickson; L. Stephen Miller; Richard G. Weleber; Vincent Cassone; David Hudson

doi:10.1016/0006-8993(88)90820-7

Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers

George C. Brainard, Alfred J. Lewy, Michael Menaker, Richard H. Fredrickson, L. Stephen Miller, Richard G. Weleber, Vincent Cassone, David Hudson

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

This study tested the capacity of different irradiances of monochromatic light to reduce plasma melatonin in normal humans. Six healthy male volunteers, 24-34 years old, were exposed to 0.01, 0.3, 1.6,5, or 13 μW/cm² of 509 nm monochromatic light for 1 h during the night on separate occasions. Light irradiance depressed plasma melatonin in a dose-response pattern. The data indicate that the mean threshold irradiance for suppressing melatonin is between 1.6 and 5μW/cm². Individual variations in threshold responses to monochromatic light were observed among the volunteers.

Original language	English
Pages (from-to)	212-218
Number of pages	7
Journal	Brain Research
Volume	454
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(88)90820-7
State	Published - Jun 28 1988

Keywords

Circadian
Light
Melatonin
Pineal
Wavelength

ASJC Scopus subject areas

Neuroscience (all)
Molecular Biology
Clinical Neurology
Developmental Biology

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title = "Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers",

abstract = "This study tested the capacity of different irradiances of monochromatic light to reduce plasma melatonin in normal humans. Six healthy male volunteers, 24-34 years old, were exposed to 0.01, 0.3, 1.6,5, or 13 μW/cm2 of 509 nm monochromatic light for 1 h during the night on separate occasions. Light irradiance depressed plasma melatonin in a dose-response pattern. The data indicate that the mean threshold irradiance for suppressing melatonin is between 1.6 and 5μW/cm2. Individual variations in threshold responses to monochromatic light were observed among the volunteers.",

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AU - Brainard, George C.

AU - Lewy, Alfred J.

AU - Menaker, Michael

AU - Fredrickson, Richard H.

AU - Miller, L. Stephen

AU - Weleber, Richard G.

AU - Cassone, Vincent

AU - Hudson, David

PY - 1988/6/28

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N2 - This study tested the capacity of different irradiances of monochromatic light to reduce plasma melatonin in normal humans. Six healthy male volunteers, 24-34 years old, were exposed to 0.01, 0.3, 1.6,5, or 13 μW/cm2 of 509 nm monochromatic light for 1 h during the night on separate occasions. Light irradiance depressed plasma melatonin in a dose-response pattern. The data indicate that the mean threshold irradiance for suppressing melatonin is between 1.6 and 5μW/cm2. Individual variations in threshold responses to monochromatic light were observed among the volunteers.

AB - This study tested the capacity of different irradiances of monochromatic light to reduce plasma melatonin in normal humans. Six healthy male volunteers, 24-34 years old, were exposed to 0.01, 0.3, 1.6,5, or 13 μW/cm2 of 509 nm monochromatic light for 1 h during the night on separate occasions. Light irradiance depressed plasma melatonin in a dose-response pattern. The data indicate that the mean threshold irradiance for suppressing melatonin is between 1.6 and 5μW/cm2. Individual variations in threshold responses to monochromatic light were observed among the volunteers.

KW - Circadian

KW - Light

KW - Melatonin

KW - Pineal

KW - Wavelength

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Dose-response relationship between light irradiance and the suppression of plasma melatonin in human volunteers

Abstract

Keywords

ASJC Scopus subject areas

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