Abstract
Recently, a novel linear brachytherapy source in the form of a coiled wire has become available for use in interstitial implants of various treatment sites such as prostate gland. This source type employs a design completely different from that of most "seed" sources currently on the market, one which improves upon or eliminates several common problems with such sources. Dosimetric characteristics of these sources with active lengths 0.5 cm to 5.0 cm were determined for clinical application. For 0.5 cm and 1.0 cm active length sources, the dose rate constant, radial dose function, and two-dimensional (2D) anisotropy function were experimentally and theoretically determined following the updated AAPM Task Group 43 (TG-43U1) recommendations. Radial dose functions and/or "along-away" matrix functions were also obtained for sources with active lengths 2.0 cm to 5.0 cm. Measurements were performed with LiF thermoluminescent dosimeters in Solid Water™ phantoms. Measured data was compared to Monte Carlo simulated data in Solid Water™ utilizing the PTRAN code, version 7.43. After finding the data to be in agreement, Monte Carlo calculations were performed in liquid water to obtain clinically applicable dosimetric data as per TG-43U1 recommendations. The results indicated the dose rate constant of the 0.5 cm long Radio-Coil™ 103Pd source in Solid Water™ to be 0.641 cGy h-1 U-1 when measured, and 0.636 cGy h-1 U-1 when simulated by Monte Carlo. The calculated dose rate constant in liquid water was found to be 0.650 cGy h -1 U-1. These values are comparable to other commercially available sources. Complete dosimetric data and simulation results are described in this paper. Per TG-43U1, clinical treatment planning systems should utilize the values reported for liquid water.
| Original language | English |
|---|---|
| Pages (from-to) | 3095-3105 |
| Number of pages | 11 |
| Journal | Medical Physics |
| Volume | 31 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2004 |
Funding
This work was partially supported by the U.S. Army Medical Research under Grant No. DAMD 17-02-1-0242.
| Funders | Funder number |
|---|---|
| U.S. Army Medical Research Acquisition Activity | DAMD 17-02-1-0242 |
Keywords
- Pd
- Brachytherapy
- Dosimetry
- Linear source
- Prostate
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
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