(matrix presented). Fused bicyclic and tricyclic compounds featuring two or three new C-C σ bonds, two new rings, two or three new stereocenters, and three new contiguous quaternary centers can be prepared stereoselectively, atom-economically, and in one synthetic operation via a cascade reaction of two nonstereogenic, readily available starting materials: a tethered bis(malononitrile) and an internal alkynone. The course of the "double annulation" changes drastically with the structure of the starting materials, alternately affording trans-decalins or cis-fused unsaturated lactones.
|Number of pages||4|
|State||Published - Nov 18 1999|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry