Addition of methyl group(s) to either or both aromatic rings of fenamic acid (FA) afforded three FA derivatives (1-3), designed to investigate the effect on the polymorphic behavior of these compounds exerted by substitution. A relatively comprehensive polymorph screen led to the discovery of four polymorphs for compound3, for which substitution took place on both aromatic rings, in contrast to the production of either two or one form(s) for compounds1and2, both of which are mono-substituted. The observation indicated that both substitution position and pattern are important in the polymorphism of these compounds. The thermal properties of each system were investigated by differential scanning calorimetry (DSC). Conformational scans and Hirshfeld surface analyses were performed to study the mechanism of polymorphism and the intermolecular interactions contributing to the stability of each crystal form.
|Number of pages||12|
|State||Published - Jan 7 2022|
Bibliographical noteFunding Information:
SL thanks Natural Science Foundation of Hubei Province for the financial support (2014CFB787). YT thanks the sponsorship from the Innovation Fund of the Graduate School (CX2020034). PZ is grateful to the Hubei Key Laboratory of Novel Reactor and Green Chemical Technology for the sponsorship (K202007).
© The Royal Society of Chemistry 2021.
ASJC Scopus subject areas
- Chemistry (all)
- Materials Science (all)
- Condensed Matter Physics