TY - JOUR
T1 - Down syndrome
T2 - age-dependence of PiB binding in postmortem frontal cortex across the lifespan
AU - LeVine, Harry
AU - Spielmann, H. Peter
AU - Matveev, Sergey
AU - Cauvi, Francesca Macchiavello
AU - Murphy, M. Paul
AU - Beckett, Tina L.
AU - McCarty, Katie
AU - Lott, Ira T.
AU - Doran, Eric
AU - Schmitt, Frederick
AU - Head, Elizabeth
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro 3H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls. Tissue from 64 cases included controls (n = 25) and DS (n = 39). In DS, 3H-PiB binding was significantly associated with age. After age 40 years in DS, 3H-PiB binding rose dramatically along with increasing individual variability. 3H-PiB binding correlated with the amount of Aβ42. Using fixed frontal tissue and fluorescent 6-CN-PiB, neuritic and cored plaques along with extensive cerebral amyloid angiopathy showed 6-CN-PiB binding. These results suggest that cortical PiB binding as shown by positron emission tomography imaging reflects plaques and cerebral amyloid angiopathy in DS brain.
AB - Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro 3H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls. Tissue from 64 cases included controls (n = 25) and DS (n = 39). In DS, 3H-PiB binding was significantly associated with age. After age 40 years in DS, 3H-PiB binding rose dramatically along with increasing individual variability. 3H-PiB binding correlated with the amount of Aβ42. Using fixed frontal tissue and fluorescent 6-CN-PiB, neuritic and cored plaques along with extensive cerebral amyloid angiopathy showed 6-CN-PiB binding. These results suggest that cortical PiB binding as shown by positron emission tomography imaging reflects plaques and cerebral amyloid angiopathy in DS brain.
KW - Aging
KW - Alzheimer disease
KW - Beta-amyloid
KW - H-X-34
KW - Neurofibrillary tangles
KW - Plaques
KW - Thioflavine S
KW - Trisomy 21
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UR - http://www.scopus.com/inward/citedby.url?scp=85017400793&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2017.03.005
DO - 10.1016/j.neurobiolaging.2017.03.005
M3 - Article
C2 - 28385551
AN - SCOPUS:85017400793
SN - 0197-4580
VL - 54
SP - 163
EP - 169
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -