Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway

Douglas A. Harrison, Patricia E. McCoon, Richard Binari, Michael Gilman, Norbert Perrimon

Research output: Contribution to journalArticlepeer-review

281 Scopus citations

Abstract

In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.

Original languageEnglish
Pages (from-to)3252-3263
Number of pages12
JournalGenes and Development
Volume12
Issue number20
DOIs
StatePublished - Oct 15 1998

Keywords

  • Hopscotch
  • JAK
  • Ligand
  • Segmentation

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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