TY - JOUR
T1 - Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway
AU - Harrison, Douglas A.
AU - McCoon, Patricia E.
AU - Binari, Richard
AU - Gilman, Michael
AU - Perrimon, Norbert
PY - 1998/10/15
Y1 - 1998/10/15
N2 - In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.
AB - In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.
KW - Hopscotch
KW - JAK
KW - Ligand
KW - Segmentation
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U2 - 10.1101/gad.12.20.3252
DO - 10.1101/gad.12.20.3252
M3 - Article
C2 - 9784499
AN - SCOPUS:0032532120
VL - 12
SP - 3252
EP - 3263
IS - 20
ER -