Drug Eluting Degradable Coatings on Biomedical Implants

Juliana C. Quarterman, Brittany E. Givens, Sean M. Geary, Aliasger K. Salem

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Biomedical implants are widely used in applications ranging from orthopedic and craniofacial to intraocular and cardiovascular. Despite their prevalence, there are still problems. For example, sometimes the implant is treated as a foreign body which can lead to the activation of inflammatory and immune responses, and eventually to implant rejection. Drug-eluting polymeric coatings (DEPCs) are one strategy employed to overcome this. A chosen drug can address the implant associated issues while additionally having an intended therapeutic effect. Depending on the physicochemical characteristics of the chosen combination of polymer and drug, such as chemical structure, degree of crystallinity, glass transition temperature, and drug content, the polymer degradation kinetics and subsequent drug release rate can be varied. However, a proposed DEPC cannot reach clinical relevance unless it meets specific criteria. It must be safe for the consumer, effectively deliver the drug within the therapeutic window, and be cost-effective to manufacture. DEPC formulations are undergoing continued improvements, and there have been encouraging experimental studies and clinical trials demonstrating their potential. On the market today, there are a multitude of degradable coatings on implants making the future of this type of delivery system highly promising.

Original languageEnglish
Title of host publicationEmerging Technologies in Biophysical Sciences
Subtitle of host publicationA World Scientific Reference: Volume 1: Emerging Technologies for Biofabrication and Biomanufacturing
Number of pages28
ISBN (Electronic)9789811225680
StatePublished - Jan 1 2022

Bibliographical note

Publisher Copyright:
© 2023 by World Scientific Publishing Co. Pte. Ltd.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Engineering
  • General Materials Science


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