Drug interactions in the horse: effect of furosemide on plasma and urinary levels of phenylbutazone

B. L. Roberts, J. W. Blake, T. Tobin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Horses pretreated with 6.6 mg/kg of phenylbutazone were injected with 1 mg/kg of furosemide intravenously. Furosemide had no clinically significant effect on either plasma levels or plasma half life of phenylbutazone. Furosemide reduced urinary levels of phenylbutazone 18 fold to concentrations which may result in inconsistent drug detection in routine screening tests. The results show that it is not possible to monitor compliance with phenylbutazone medication rules by means of urinalysis alone if the use of furosemide is permitted. Furosemide treatment, however, does not interfere with monitoring by plasma level determinations.

Original languageEnglish
Pages (from-to)257-265
Number of pages9
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume15
Issue number2
StatePublished - 1976

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics (all)

Fingerprint

Dive into the research topics of 'Drug interactions in the horse: effect of furosemide on plasma and urinary levels of phenylbutazone'. Together they form a unique fingerprint.

Cite this