Dynamic manipulation and patterning of breast cancer cells in biosolution

Hao Jia; Hao Tang; Anika Rede; Xia Liu; Huiping Liu; Philip X.L. Feng

doi:10.1109/MEMSYS.2017.7863470

Dynamic manipulation and patterning of breast cancer cells in biosolution

Hao Jia, Hao Tang, Anika Rede, Xia Liu, Huiping Liu, Philip X.L. Feng

Toxicology and Cancer Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

This paper reports the first experimental exploration of non-invasive and fast manipulation of breast cancer cells by harnessing multimode micromechanical resonators operating in biosolution. We demonstrate, for the first time, that groups of breast cancer cells are spatially manipulated into controlled microscale patterns, facilitated by the spatially abundant and diverse multimode resonances of vibrating thin micro-diaphragms. We further show that these cell patterns can be dynamically switched within 30s via programmed excitation frequencies, exhibiting a cell manipulation speed at ∼4μm/s. The results demonstrate a versatile platform for cell manipulation and patterning at microscale, which may facilitate breast cancer related studies at cellular level.

Original language	English
Title of host publication	2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017
Pages	569-572
Number of pages	4
ISBN (Electronic)	9781509050789
DOIs	https://doi.org/10.1109/MEMSYS.2017.7863470
State	Published - Feb 23 2017
Event	30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States Duration: Jan 22 2017 → Jan 26 2017

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017
Country/Territory	United States
City	Las Vegas
Period	1/22/17 → 1/26/17

Bibliographical note

Funding Information:
We thank the financial support from National Science Foundation (ECCS-1408494). H.L. and X.L. acknowledge the financial support under NIH/NCI R00CA160638 and DOD W81XWH-16-1-0021 (HL).

Publisher Copyright:
© 2017 IEEE.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/MEMSYS.2017.7863470

Cite this

Jia, H., Tang, H., Rede, A., Liu, X., Liu, H., & Feng, P. X. L. (2017). Dynamic manipulation and patterning of breast cancer cells in biosolution. In 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017 (pp. 569-572). Article 7863470 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2017.7863470

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title = "Dynamic manipulation and patterning of breast cancer cells in biosolution",

abstract = "This paper reports the first experimental exploration of non-invasive and fast manipulation of breast cancer cells by harnessing multimode micromechanical resonators operating in biosolution. We demonstrate, for the first time, that groups of breast cancer cells are spatially manipulated into controlled microscale patterns, facilitated by the spatially abundant and diverse multimode resonances of vibrating thin micro-diaphragms. We further show that these cell patterns can be dynamically switched within 30s via programmed excitation frequencies, exhibiting a cell manipulation speed at ∼4μm/s. The results demonstrate a versatile platform for cell manipulation and patterning at microscale, which may facilitate breast cancer related studies at cellular level.",

author = "Hao Jia and Hao Tang and Anika Rede and Xia Liu and Huiping Liu and Feng, {Philip X.L.}",

note = "Funding Information: We thank the financial support from National Science Foundation (ECCS-1408494). H.L. and X.L. acknowledge the financial support under NIH/NCI R00CA160638 and DOD W81XWH-16-1-0021 (HL). Publisher Copyright: {\textcopyright} 2017 IEEE.; 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 ; Conference date: 22-01-2017 Through 26-01-2017",

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doi = "10.1109/MEMSYS.2017.7863470",

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Jia, H, Tang, H, Rede, A, Liu, X, Liu, H & Feng, PXL 2017, Dynamic manipulation and patterning of breast cancer cells in biosolution. in 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017., 7863470, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 569-572, 30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017, Las Vegas, United States, 1/22/17. https://doi.org/10.1109/MEMSYS.2017.7863470

Dynamic manipulation and patterning of breast cancer cells in biosolution. / Jia, Hao; Tang, Hao; Rede, Anika et al.
2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017. 2017. p. 569-572 7863470 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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N1 - Funding Information: We thank the financial support from National Science Foundation (ECCS-1408494). H.L. and X.L. acknowledge the financial support under NIH/NCI R00CA160638 and DOD W81XWH-16-1-0021 (HL). Publisher Copyright: © 2017 IEEE.

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N2 - This paper reports the first experimental exploration of non-invasive and fast manipulation of breast cancer cells by harnessing multimode micromechanical resonators operating in biosolution. We demonstrate, for the first time, that groups of breast cancer cells are spatially manipulated into controlled microscale patterns, facilitated by the spatially abundant and diverse multimode resonances of vibrating thin micro-diaphragms. We further show that these cell patterns can be dynamically switched within 30s via programmed excitation frequencies, exhibiting a cell manipulation speed at ∼4μm/s. The results demonstrate a versatile platform for cell manipulation and patterning at microscale, which may facilitate breast cancer related studies at cellular level.

AB - This paper reports the first experimental exploration of non-invasive and fast manipulation of breast cancer cells by harnessing multimode micromechanical resonators operating in biosolution. We demonstrate, for the first time, that groups of breast cancer cells are spatially manipulated into controlled microscale patterns, facilitated by the spatially abundant and diverse multimode resonances of vibrating thin micro-diaphragms. We further show that these cell patterns can be dynamically switched within 30s via programmed excitation frequencies, exhibiting a cell manipulation speed at ∼4μm/s. The results demonstrate a versatile platform for cell manipulation and patterning at microscale, which may facilitate breast cancer related studies at cellular level.

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Dynamic manipulation and patterning of breast cancer cells in biosolution

Abstract

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Bibliographical note

ASJC Scopus subject areas

UN SDGs

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