This paper reports the first experimental exploration of non-invasive and fast manipulation of breast cancer cells by harnessing multimode micromechanical resonators operating in biosolution. We demonstrate, for the first time, that groups of breast cancer cells are spatially manipulated into controlled microscale patterns, facilitated by the spatially abundant and diverse multimode resonances of vibrating thin micro-diaphragms. We further show that these cell patterns can be dynamically switched within 30s via programmed excitation frequencies, exhibiting a cell manipulation speed at ∼4μm/s. The results demonstrate a versatile platform for cell manipulation and patterning at microscale, which may facilitate breast cancer related studies at cellular level.
|Title of host publication||2017 IEEE 30th International Conference on Micro Electro Mechanical Systems, MEMS 2017|
|Number of pages||4|
|State||Published - Feb 23 2017|
|Event||30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017 - Las Vegas, United States|
Duration: Jan 22 2017 → Jan 26 2017
|Name||Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)|
|Conference||30th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2017|
|Period||1/22/17 → 1/26/17|
Bibliographical noteFunding Information:
We thank the financial support from National Science Foundation (ECCS-1408494). H.L. and X.L. acknowledge the financial support under NIH/NCI R00CA160638 and DOD W81XWH-16-1-0021 (HL).
© 2017 IEEE.
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Mechanical Engineering
- Electrical and Electronic Engineering