Dysregulation of Cellular Signaling by HER2/neu in Breast Cancer

Binhua P. Zhou, Mien Chie Hung

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

Human epidermal growth factor receptor-2 (HER2/neu; erbB2) belongs to a family of four transmembrane receptor tyrosine kinases involved in signal transduction pathways that regulate cell growth and proliferation. Amplification or overexpression of HER2/neu occurs in about 30% of human breast and ovarian cancers and is associated with a poor clinical outcome, including short survival time and short time to relapse. Recent advances in our understanding of HER2/neu signaling pathways have greatly increased our knowledge of breast cancer tumorigenesis and have provided new targets for treating breast and ovarian tumors that overexpress HER2/neu. This review will focus on the signaling network mediated by HER2/neu in breast cancer and discuss our understanding of these pathways, which seem to be particularly important in mediating cell survival and growth under a wide variety of circumstances in breast cancer.

Original languageEnglish
Pages (from-to)38-48
Number of pages11
JournalSeminars in Oncology
Volume30
Issue number5 SUPPL. 16
DOIs
StatePublished - Oct 2003

Bibliographical note

Funding Information:
Supported by National Institutes of Health grant nos. CA 58880, CA 77858, and CA 78633; by a SPORE grant in ovarian cancer (CA 83639) (M.-C. H.); and by the Nellie Connally Breast Cancer Research Fund at The University of Texas M. D. Anderson Cancer Center (M.-C. H.).

ASJC Scopus subject areas

  • Hematology
  • Oncology

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