TY - JOUR
T1 - Dysregulation of cytokine mediated chemotherapy induced cognitive impairment
AU - Ren, Xiaojia
AU - St. Clair, Daret K.
AU - Butterfield, D. Allan
N1 - Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/3/1
Y1 - 2017/3/1
N2 - One of the major complaints patients who survive cancer often make is chemotherapy induced cognitive impairment (CICI), which survivors often call “chemo brain.” CICI is a side effect of chemotherapy due to the cytotoxicity and neurotoxicity of anti-cancer drugs causing structural and functional changes in brain, even when drugs that do not cross the blood brain barrier (BBB) are used. Diminished cognitive functions including diminution of learning and memory, concentration and attention, processing speed and executive functions that reduce quality of life and ability to work are common signs and symptoms of CICI. There still is not a clarified and complete mechanism for CICI, but researchers have pointed to several biochemical candidates. Chemotherapy-induced, cytokine-mediated involvement in CICI will be mainly discussed in this review paper with emphasis on different types of cytokines, correlated with BBB and epigenetic changes. Mechanisms of ROS-generating, anti-cancer drugs and their relation to cytokine-mediated CICI will be emphasized.
AB - One of the major complaints patients who survive cancer often make is chemotherapy induced cognitive impairment (CICI), which survivors often call “chemo brain.” CICI is a side effect of chemotherapy due to the cytotoxicity and neurotoxicity of anti-cancer drugs causing structural and functional changes in brain, even when drugs that do not cross the blood brain barrier (BBB) are used. Diminished cognitive functions including diminution of learning and memory, concentration and attention, processing speed and executive functions that reduce quality of life and ability to work are common signs and symptoms of CICI. There still is not a clarified and complete mechanism for CICI, but researchers have pointed to several biochemical candidates. Chemotherapy-induced, cytokine-mediated involvement in CICI will be mainly discussed in this review paper with emphasis on different types of cytokines, correlated with BBB and epigenetic changes. Mechanisms of ROS-generating, anti-cancer drugs and their relation to cytokine-mediated CICI will be emphasized.
KW - Cancer chemotherapy
KW - Chemobrain
KW - Cognition dysfunction
KW - Cytokines and epigenetics changes
UR - http://www.scopus.com/inward/record.url?scp=85008967671&partnerID=8YFLogxK
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U2 - 10.1016/j.phrs.2017.01.001
DO - 10.1016/j.phrs.2017.01.001
M3 - Review article
C2 - 28063894
AN - SCOPUS:85008967671
SN - 1043-6618
VL - 117
SP - 267
EP - 273
JO - Pharmacological Research
JF - Pharmacological Research
ER -
