Dysregulation of cytokine mediated chemotherapy induced cognitive impairment

Xiaojia Ren, Daret K. St. Clair, D. Allan Butterfield

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


One of the major complaints patients who survive cancer often make is chemotherapy induced cognitive impairment (CICI), which survivors often call “chemo brain.” CICI is a side effect of chemotherapy due to the cytotoxicity and neurotoxicity of anti-cancer drugs causing structural and functional changes in brain, even when drugs that do not cross the blood brain barrier (BBB) are used. Diminished cognitive functions including diminution of learning and memory, concentration and attention, processing speed and executive functions that reduce quality of life and ability to work are common signs and symptoms of CICI. There still is not a clarified and complete mechanism for CICI, but researchers have pointed to several biochemical candidates. Chemotherapy-induced, cytokine-mediated involvement in CICI will be mainly discussed in this review paper with emphasis on different types of cytokines, correlated with BBB and epigenetic changes. Mechanisms of ROS-generating, anti-cancer drugs and their relation to cytokine-mediated CICI will be emphasized.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalPharmacological Research
StatePublished - Mar 1 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd


  • Cancer chemotherapy
  • Chemobrain
  • Cognition dysfunction
  • Cytokines and epigenetics changes

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Dysregulation of cytokine mediated chemotherapy induced cognitive impairment'. Together they form a unique fingerprint.

Cite this