Dysregulations of long non-coding RNAs − The emerging “lnc” in environmental carcinogenesis

Po Shun Wang, Zhishan Wang, Chengfeng Yang

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Long non-coding RNAs (lncRNAs) refer to a class of RNA molecules that are more than 200 nucleotides in length and usually lack protein-coding capacity. LncRNAs play important roles in regulating gene expression as well as many aspects of normal physiological processes. Dysregulations of lncRNA expressions and functions are considered to be critically involved in the development and progression of many diseases especially cancer. The lncRNA research in the field of cancer biology over the past decade reveals that a large number of lncRNAs are dysregulated in various types of cancer and that dysregulated lncRNAs may play important roles in cancer initiation, metastasis and therapeutic responses. Metal carcinogens and other common environmental carcinogens such as polycyclic aromatic hydrocarbons, fine particular matters, cigarette smoke, ultraviolet and ionizing radiation are important cancer etiology factors. However, the mechanisms of how metal carcinogens and other common environmental carcinogen exposures initiate cancer and promote cancer progression remain largely unknown. Accumulating evidence show that exposure to metal carcinogens and other common environmental carcinogens dysregulate lncRNA expression in various model systems, which may offer novel mechanistic insights for environmental carcinogenesis. This review will first provide a brief introduction about lncRNA biology and the mechanisms of lncRNA functions, followed by summarizing and discussing recent studies about lncRNA dysregulation by metal carcinogen and other common environment carcinogen exposures and the potential roles of dysregulated lncRNAs in environmental carcinogenesis. A perspective for future studies in this emerging and important field is also presented.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalSeminars in Cancer Biology
StatePublished - Nov 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health ( R01ES026151 ; R01ES028256 ; R01ES029496 ; R01ES029942 ).

Publisher Copyright:
© 2021 Elsevier Ltd


  • Arsenic
  • Cadmium
  • Chromium
  • Environmental carcinogenesis
  • Environmental carcinogens
  • Epigenetics
  • Long non-coding RNAs
  • Metal carcinogenesis
  • Metals
  • Nickel

ASJC Scopus subject areas

  • Cancer Research


Dive into the research topics of 'Dysregulations of long non-coding RNAs − The emerging “lnc” in environmental carcinogenesis'. Together they form a unique fingerprint.

Cite this