Our previous preclinical study demonstrated that both visible diffuse reflectance and autofluorescence spectroscopy, each of which yields a different set of physiological information, can predict skin flap viability with high accuracy in a MacFarlane rat dorsal skin flap model. In this report, we further evaluated our technique for the early detection and differentiation of venous occlusion and arterial occlusion in a rat groin flap model. We performed both diffuse reflectance and autofluorescence measurements on the skin flap model and statistically differentiated between flaps with and without occlusions as well as between flaps with venous occlusion and those with arterial occlusion based on these noninvasive optical measurements. Our preliminary results suggested that visible diffuse reflectance and autofluorescence spectroscopy can be potentially used clinically to detect both venous and arterial occlusion and differentiate one from the other accurately at an early time point.
|Number of pages||11|
|Journal||Biomedical Optics Express|
|State||Published - Jan 19 2016|
Bibliographical notePublisher Copyright:
© 2016 Optical Society of America.
- Blood or tissue constituent monitoring
- Optical diagnostics for medicine
- Tissue characterization
- Tissue diagnostics
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics