Early detection of ovarian tumors using ultrasound

Edward J. Pavlik, John R. Van Nagell

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Ovarian cancer can be treated with a very good prognosis if detected in the early stages, but not after it has advanced. Transvaginal ultrasound is capable of identifying changes in ovarian size and structure, and thereby detects early ovarian malignancies. This view has generated four major trials on transvaginal ultrasound detection: the Kentucky, PLCO, UKCTOCS, and SCSOCS trials. Each is sufficiently different to warrant examination. The Kentucky, UKCTOCS and SCSOCS trials report a shift to early stage detection. The Kentucky trial reports a survival benefit, while follow-up survival analysis is pending in the UKCTOCS and SCSOCS trials. Details of these trials are presented including definitions, inclusions/exclusions, analytic structure (intention-to-treat vs per protocol), performance (sensitivity, specificity, positive predictive value and negative predictive value), extent of screeningrelated treatment, time from screening to treatment, length of follow-up and survival versus mortality analysis. Questions are answered here about effectiveness, application, prevalence, cost and the potential for harm.

Original languageEnglish
Pages (from-to)39-57
Number of pages19
JournalWomen's Health
Issue number1
StatePublished - Jan 2013


  • morphology indexing
  • ovary
  • screening
  • serial transvaginal ultrasound

ASJC Scopus subject areas

  • General Medicine


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