TY - JOUR
T1 - Early emergency department experience with 7-day extended-release injectable buprenorphine for opioid use disorder
AU - D'Onofrio, Gail
AU - Perrone, Jeanmarie
AU - Hawk, Kathryn F.
AU - Cowan, Ethan
AU - McCormack, Ryan
AU - Coupet, Edouard
AU - Owens, Patricia H.
AU - Martel, Shara H.
AU - Huntley, Kristen
AU - Walsh, Sharon L.
AU - Lofwall, Michelle R.
AU - Herring, Andrew
N1 - Publisher Copyright:
© 2023 The Authors. Academic Emergency Medicine published by Wiley Periodicals LLC on behalf of Society for Academic Emergency Medicine.
PY - 2023/12
Y1 - 2023/12
N2 - As the opioid overdose epidemic escalates, there is an urgent need for treatment innovations to address both patient and clinician barriers when initiating buprenorphine in the emergency department (ED). These include insurance status, logistical challenges such as the ability to fill a prescription and transportation, concerns regarding diversion, and availability of urgent referral sites. Extended-release buprenorphine (XR-BUP) preparations such as a new 7-day injectable could potentially solve some of these issues. We describe the pharmacokinetics of a new 7-day XR-BUP formulation and the feasibility of its use in the ED setting. We report our early experiences with this medication (investigational drug CAM2038), in the context of an ongoing clinical trial entitled Emergency Department-Initiated BUP VAlidaTION (ED INNOVATION), to inform emergency clinicians as they consider incorporating this medication into their practice. The medication was approved by the European Medicines Agency in 2018 and the U.S. Food and Drug Administration in 2023 for those 18 years or older for the treatment of moderate to severe opioid use disorder (OUD). We report our experience with approximately 800 ED patients with OUD who received the 7-day XR-BUP preparation in the ED between June 2020 and July 2023.
AB - As the opioid overdose epidemic escalates, there is an urgent need for treatment innovations to address both patient and clinician barriers when initiating buprenorphine in the emergency department (ED). These include insurance status, logistical challenges such as the ability to fill a prescription and transportation, concerns regarding diversion, and availability of urgent referral sites. Extended-release buprenorphine (XR-BUP) preparations such as a new 7-day injectable could potentially solve some of these issues. We describe the pharmacokinetics of a new 7-day XR-BUP formulation and the feasibility of its use in the ED setting. We report our early experiences with this medication (investigational drug CAM2038), in the context of an ongoing clinical trial entitled Emergency Department-Initiated BUP VAlidaTION (ED INNOVATION), to inform emergency clinicians as they consider incorporating this medication into their practice. The medication was approved by the European Medicines Agency in 2018 and the U.S. Food and Drug Administration in 2023 for those 18 years or older for the treatment of moderate to severe opioid use disorder (OUD). We report our experience with approximately 800 ED patients with OUD who received the 7-day XR-BUP preparation in the ED between June 2020 and July 2023.
KW - injectable buprenorphine
KW - medications for opioid use disorder
KW - opioid use disorder treatment
UR - http://www.scopus.com/inward/record.url?scp=85168680246&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85168680246&partnerID=8YFLogxK
U2 - 10.1111/acem.14782
DO - 10.1111/acem.14782
M3 - Article
C2 - 37501652
AN - SCOPUS:85168680246
SN - 1069-6563
VL - 30
SP - 1264
EP - 1271
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
IS - 12
ER -