Early growth response-1-dependent apoptosis is mediated by p53

Prakash Nair, Sumathi Muthukkumar, Stephen F. Sells, Seong Su Han, Vikas P. Sukhatme, Vivek M. Rangnekar

Research output: Contribution to journalArticlepeer-review

165 Scopus citations

Abstract

The early growth response-1 (EGR-1) protein is an anti-proliferative signal for certain tumor cells and is required for apoptosis induced by stimuli that elevate intracellular Ca2+. We present evidence that EGR-1 transactivates the promoter of the p53 gene and up-regulates p53 RNA and protein levels. Inhibition of p53 function with dominant-negative p53 mutants abrogates EGR-1-dependent apoptosis. These findings establish a direct functional link between EGR-1 and the p53-mediated cell death pathway and suggest that mutant forms of p53 in tumor cells may provide resistance to the antiproliferative effects of EGR-1.

Original languageEnglish
Pages (from-to)20131-20138
Number of pages8
JournalJournal of Biological Chemistry
Volume272
Issue number32
DOIs
StatePublished - Aug 8 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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