TY - JOUR
T1 - Early growth response-1-dependent apoptosis is mediated by p53
AU - Nair, Prakash
AU - Muthukkumar, Sumathi
AU - Sells, Stephen F.
AU - Han, Seong Su
AU - Sukhatme, Vikas P.
AU - Rangnekar, Vivek M.
PY - 1997/8/8
Y1 - 1997/8/8
N2 - The early growth response-1 (EGR-1) protein is an anti-proliferative signal for certain tumor cells and is required for apoptosis induced by stimuli that elevate intracellular Ca2+. We present evidence that EGR-1 transactivates the promoter of the p53 gene and up-regulates p53 RNA and protein levels. Inhibition of p53 function with dominant-negative p53 mutants abrogates EGR-1-dependent apoptosis. These findings establish a direct functional link between EGR-1 and the p53-mediated cell death pathway and suggest that mutant forms of p53 in tumor cells may provide resistance to the antiproliferative effects of EGR-1.
AB - The early growth response-1 (EGR-1) protein is an anti-proliferative signal for certain tumor cells and is required for apoptosis induced by stimuli that elevate intracellular Ca2+. We present evidence that EGR-1 transactivates the promoter of the p53 gene and up-regulates p53 RNA and protein levels. Inhibition of p53 function with dominant-negative p53 mutants abrogates EGR-1-dependent apoptosis. These findings establish a direct functional link between EGR-1 and the p53-mediated cell death pathway and suggest that mutant forms of p53 in tumor cells may provide resistance to the antiproliferative effects of EGR-1.
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U2 - 10.1074/jbc.272.32.20131
DO - 10.1074/jbc.272.32.20131
M3 - Article
C2 - 9242687
AN - SCOPUS:0030872497
SN - 0021-9258
VL - 272
SP - 20131
EP - 20138
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 32
ER -