TY - JOUR
T1 - Early onset oral tongue cancer in the United States
T2 - A literature review
AU - Campbell, Benjamin R.
AU - Netterville, James L.
AU - Sinard, Robert J.
AU - Mannion, Kyle
AU - Rohde, Sarah L.
AU - Langerman, Alexander
AU - Kim, Young J.
AU - Lewis, James S.
AU - Lang Kuhs, Krystle A.
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - The incidence of early onset oral tongue squamous cell carcinoma (OTC) has been increasing in the United States, and no clear etiology has been identified. Studies on this topic have generally been small and presented varied results. The goal of this review is to analyze and synthesize the literature regarding early onset OTC risk factors, outcomes, and molecular analyses within the US. To date, studies suggest that early onset OTC patients tend to have less heavy cigarette use than typical onset patients, but there may be an association between early onset OTC and smokeless tobacco (chewing tobacco and snuff) use. Early onset OTC is associated with similar or possibly improved survival compared to typical onset OTC. There has been no evidence to support a significant role for human papillomavirus in development of early onset OTC. Further research with larger cohorts of these patients is needed to better characterize this disease entity.
AB - The incidence of early onset oral tongue squamous cell carcinoma (OTC) has been increasing in the United States, and no clear etiology has been identified. Studies on this topic have generally been small and presented varied results. The goal of this review is to analyze and synthesize the literature regarding early onset OTC risk factors, outcomes, and molecular analyses within the US. To date, studies suggest that early onset OTC patients tend to have less heavy cigarette use than typical onset patients, but there may be an association between early onset OTC and smokeless tobacco (chewing tobacco and snuff) use. Early onset OTC is associated with similar or possibly improved survival compared to typical onset OTC. There has been no evidence to support a significant role for human papillomavirus in development of early onset OTC. Further research with larger cohorts of these patients is needed to better characterize this disease entity.
KW - Early onset
KW - Human papillomavirus
KW - Molecular
KW - Oral tongue
KW - Recurrence
KW - Squamous cell carcinoma
KW - Survival
KW - Tobacco
KW - United States
KW - Young
UR - http://www.scopus.com/inward/record.url?scp=85054731178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054731178&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2018.10.009
DO - 10.1016/j.oraloncology.2018.10.009
M3 - Review article
C2 - 30527223
AN - SCOPUS:85054731178
VL - 87
SP - 1
EP - 7
ER -
