Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Benjamin R. Campbell; Courtney B. Sanders; James L. Netterville; Robert J. Sinard; Sarah L. Rohde; Alexander Langerman; Kyle Mannion; Young J. Kim; Barbara A. Murphy; James S. Lewis; Jeremy L. Warner; Derek K. Smith; Krystle A. Lang Kuhs

doi:10.1002/hed.25650

Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Benjamin R. Campbell, Courtney B. Sanders, James L. Netterville, Robert J. Sinard, Sarah L. Rohde, Alexander Langerman, Kyle Mannion, Young J. Kim, Barbara A. Murphy, James S. Lewis, Jeremy L. Warner, Derek K. Smith, Krystle A. Lang Kuhs

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.

Original language	English
Pages (from-to)	1952-1960
Number of pages	9
Journal	Head and Neck
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/hed.25650
State	Published - Jun 2019

Bibliographical note

Funding Information:
This work was supported by Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445 from NCATS/ NIH) and Vanderbilt University Medical Center institutional funding.

Funding Information:
This work was supported by Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445 from NCATS/NIH) and Vanderbilt University Medical Center institutional funding.

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Keywords

oral tongue
snuff
squamous cell carcinoma
tobacco
young

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.25650

Cite this

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title = "Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes",

abstract = "Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.",

keywords = "oral tongue, snuff, squamous cell carcinoma, tobacco, young",

author = "Campbell, {Benjamin R.} and Sanders, {Courtney B.} and Netterville, {James L.} and Sinard, {Robert J.} and Rohde, {Sarah L.} and Alexander Langerman and Kyle Mannion and Kim, {Young J.} and Murphy, {Barbara A.} and Lewis, {James S.} and Warner, {Jeremy L.} and Smith, {Derek K.} and {Lang Kuhs}, {Krystle A.}",

note = "Funding Information: This work was supported by Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445 from NCATS/ NIH) and Vanderbilt University Medical Center institutional funding. Funding Information: This work was supported by Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445 from NCATS/NIH) and Vanderbilt University Medical Center institutional funding. Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

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doi = "10.1002/hed.25650",

language = "English",

volume = "41",

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T2 - Associated factors and patient outcomes

AU - Campbell, Benjamin R.

AU - Sanders, Courtney B.

AU - Netterville, James L.

AU - Sinard, Robert J.

AU - Rohde, Sarah L.

AU - Langerman, Alexander

AU - Mannion, Kyle

AU - Kim, Young J.

AU - Murphy, Barbara A.

AU - Lewis, James S.

AU - Warner, Jeremy L.

AU - Smith, Derek K.

AU - Lang Kuhs, Krystle A.

N1 - Funding Information: This work was supported by Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445 from NCATS/ NIH) and Vanderbilt University Medical Center institutional funding. Funding Information: This work was supported by Vanderbilt Institute for Clinical and Translational Research (UL1 TR000445 from NCATS/NIH) and Vanderbilt University Medical Center institutional funding. Publisher Copyright: © 2019 Wiley Periodicals, Inc.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.

AB - Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.

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Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes

Abstract

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Keywords

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