TY - JOUR
T1 - Early onset oral tongue squamous cell carcinoma
T2 - Associated factors and patient outcomes
AU - Campbell, Benjamin R.
AU - Sanders, Courtney B.
AU - Netterville, James L.
AU - Sinard, Robert J.
AU - Rohde, Sarah L.
AU - Langerman, Alexander
AU - Mannion, Kyle
AU - Kim, Young J.
AU - Murphy, Barbara A.
AU - Lewis, James S.
AU - Warner, Jeremy L.
AU - Smith, Derek K.
AU - Lang Kuhs, Krystle A.
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/6
Y1 - 2019/6
N2 - Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.
AB - Background: Incidence of oral tongue squamous cell carcinoma (OTC) is rising among those under age 50 years. The etiology is unknown. Methods: A total of 395 cases of OTC diagnosed and/or treated at Vanderbilt University Medical Center between 2000 and 2017 were identified. Of those, 113 (28.6%) were early onset (age < 50 years). Logistic regression was used to identify factors associated with early onset OTC. Cox proportional hazards models evaluated survival and recurrence. Results: Compared to typical onset patients, patients with early onset OTC were more likely to receive multimodality treatment (surgery and radiation; adjusted odds ratio [aOR], 2.7; 95% confidence interval [CI], 1.2-6.3) and report a history of snuff use (aOR, 5.4; 95% CI, 1.8-15.8) and were less likely to report a history of cigarette use (aOR, 0.5; 95% CI, 0.2-0.9). Early onset patients had better overall survival (adjusted hazard ratio, 0.6). Conclusions: This is the largest study to evaluate factors associated with early onset OTC and the first to report an association with snuff.
KW - oral tongue
KW - snuff
KW - squamous cell carcinoma
KW - tobacco
KW - young
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U2 - 10.1002/hed.25650
DO - 10.1002/hed.25650
M3 - Article
C2 - 30633435
AN - SCOPUS:85059891797
SN - 1043-3074
VL - 41
SP - 1952
EP - 1960
JO - Head and Neck
JF - Head and Neck
IS - 6
ER -