TY - JOUR
T1 - Ectopic expression of musashi-1 in Alzheimer disease and Pick disease
AU - Lovell, Mark A.
AU - Markesbery, William R.
PY - 2005/8
Y1 - 2005/8
N2 - Abnormal accumulation of proteins in filamentous cytoplasmic inclusions is a hallmark of several neurodegenerative disorders, including Alzheimer disease (AD) and Pick disease (PD). Musashi-1 (Msi-1), an RNA-binding protein associated with neural progenitor cells, has been shown by others to increase the accumulation of tau isoforms in intracellular inclusions in frontotemporal dementia and parkinsonism linked to chromosome 17. We investigated the expression of Msi-1 in the hippocampus of AD, PD, and aged normal control subjects using immunohistochemistry. Comparison of immediately adjacent serial sections stained using the modified Bielschowsky method and immunostained for Msi-1 showed that Msi-1 was present in 83 ± 6% of neurofibrillary tangle bearing neurons in AD and 94 ± 14% of Pick bodies in PD specimens. Aged control hippocampus demonstrated virtually no Msi-1 immunostaining. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 different neurodegenerative diseases suggests that it may play a role in the pathogenesis of these lesions.
AB - Abnormal accumulation of proteins in filamentous cytoplasmic inclusions is a hallmark of several neurodegenerative disorders, including Alzheimer disease (AD) and Pick disease (PD). Musashi-1 (Msi-1), an RNA-binding protein associated with neural progenitor cells, has been shown by others to increase the accumulation of tau isoforms in intracellular inclusions in frontotemporal dementia and parkinsonism linked to chromosome 17. We investigated the expression of Msi-1 in the hippocampus of AD, PD, and aged normal control subjects using immunohistochemistry. Comparison of immediately adjacent serial sections stained using the modified Bielschowsky method and immunostained for Msi-1 showed that Msi-1 was present in 83 ± 6% of neurofibrillary tangle bearing neurons in AD and 94 ± 14% of Pick bodies in PD specimens. Aged control hippocampus demonstrated virtually no Msi-1 immunostaining. The presence of Msi-1 in a significant percentage of neurons containing cytoplasmic inclusions in 2 different neurodegenerative diseases suggests that it may play a role in the pathogenesis of these lesions.
KW - Alzheimer disease
KW - Neurofibrillary tangles (NFT)
KW - Pick bodies
KW - Tau
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UR - http://www.scopus.com/inward/citedby.url?scp=23844558036&partnerID=8YFLogxK
U2 - 10.1097/01.jnen.0000173891.17176.5b
DO - 10.1097/01.jnen.0000173891.17176.5b
M3 - Article
C2 - 16106215
AN - SCOPUS:23844558036
SN - 0022-3069
VL - 64
SP - 675
EP - 680
JO - Journal of Neuropathology and Experimental Neurology
JF - Journal of Neuropathology and Experimental Neurology
IS - 8
ER -