Ectopic fat accumulation and metabolic syndrome

Neda Rasouli, Behzad Molavi, Steven C. Elbein, Philip A. Kern

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations

Abstract

The recent escalation of obesity from an individual health problem to a major public health issue reaching epidemic proportions has drawn attention to a constellation of abnormalities (abdominal obesity, hypertension and dyslipidaemia) collectively referred to as metabolic syndrome. As an indicator of insulin resistance and a harbinger of diabetes, this syndrome has been associated with major cardiovascular mortality and morbidity. Yet, the exact pathophysiological events leading to the development of metabolic syndrome remain unknown. We review some of the current literature on the pathogenesis of metabolic syndrome with an emphasis on the role of ectopic lipid accumulation.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalDiabetes, Obesity and Metabolism
Volume9
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Adipose tissue
  • Ectopic fat
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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