EEG changes in a patient with steroid-responsive encephalopathy associated with antibodies to thyroperoxidase (SREAT, Hashimoto's encephalopathy)

Alcibiades J. Rodriguez, Gregory A. Jicha, Thomas D.L. Steeves, Eduardo E. Benarroch, Barbara F. Westmoreland

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A 56-year-old woman presented with an acute confusional state and moderate global aphasia. Thyroperoxidase antibody level was elevated (3,890 IU/mL) and SREAT was diagnosed. MRI findings were normal. Cerebrospinal fluid examination revealed only a mildly increased protein. The initial electroencephalogram EEG showed slowing and markedly decreased amplitude over the left hemisphere and left temporal sharp waves. An EEG performed after treatment with intravenous steroids showed a significant improvement of the background slowing, which correlated with clinical improvement. One week later, the patient had an episode of forced head-turning and fencing posture to the right. The EEG shortly afterward showed slowing and a decreased amplitude over the right hemisphere. Continuous EEG monitoring was performed at the time of steroid treatment. Again, there was a significant improvement of the EEG after this treatment that correlated with the clinical condition. SREAT is characterized by fluctuations in mental status and variable EEG findings. These patients often show an excellent clinical improvement to immunosuppressive therapy, including corticosteroids. This case report documents the dramatic clinical and EEG improvement with steroid therapy.

Original languageEnglish
Pages (from-to)371-373
Number of pages3
JournalJournal of Clinical Neurophysiology
Volume23
Issue number4
DOIs
StatePublished - Aug 2006

Keywords

  • Antibodies
  • EEG
  • SREAT (Hashimoto's encephalopathy)
  • Steroids
  • Thyroperoxidase

ASJC Scopus subject areas

  • Physiology
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'EEG changes in a patient with steroid-responsive encephalopathy associated with antibodies to thyroperoxidase (SREAT, Hashimoto's encephalopathy)'. Together they form a unique fingerprint.

Cite this