EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease

Joseph McBride; Xiaopeng Zhao; Nancy Munro; Gregory Jicha; Charles Smith; Yang Jiang

doi:10.1109/BSEC.2014.6867738

EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease

Joseph McBride, Xiaopeng Zhao, Nancy Munro, Gregory Jicha, Charles Smith, Yang Jiang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

8 Scopus citations

Abstract

Mild cognitive impairment (MCI) is a neurological condition that is ofte. The early stage of Alzheimer's disease (AD). This pilot study explores event-related multiscale entropy (MSE) measures as features for effectively discriminating between normal aging, MCI, and AD participants. Thirty two-channel scalp EEG records recorded during a working memory task from 43 age-matched participants (mean age 75.7 years)-17 normal controls (NC), 16 MCI, and 10 early ADare examined. Multiscale entropy curves are computed for responses durin. The working memory task. Support vector machine models are constructed to perform binary discriminations amon. The three groups. Leave-one-out cross-validation accuracies of 87.9% (p-value <1.322E-4) for MCI vs. NC, 88.9% (p-value <2.886E-5) for AD vs. NC, and 92.3% (p-value <4.910E-6) for MCI vs. AD are achieved. Results demonstrate links between event-related multiscale entropy dynamics of EEG and short-term memory deficits.

Original language	English
Title of host publication	Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference
Subtitle of host publication	Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014
ISBN (Electronic)	9781479941599
DOIs	https://doi.org/10.1109/BSEC.2014.6867738
State	Published - Jul 29 2014
Event	5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014 - Oak Ridge, United States Duration: May 6 2014 → May 8 2014

Publication series

Name	Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014

Conference

Conference	5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014
Country/Territory	United States
City	Oak Ridge
Period	5/6/14 → 5/8/14

Bibliographical note

Publisher Copyright:
© 2014 IEEE.

Keywords

Alzheimer's disease
EEG
mild cognitive impairment
multiscale entropy

ASJC Scopus subject areas

Neuroscience (all)
Biomedical Engineering

Access to Document

10.1109/BSEC.2014.6867738

Cite this

McBride, J., Zhao, X., Munro, N., Jicha, G., Smith, C., & Jiang, Y. (2014). EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease. In Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014 Article 6867738 (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014). https://doi.org/10.1109/BSEC.2014.6867738

McBride, Joseph ; Zhao, Xiaopeng ; Munro, Nancy et al. / EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease. Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014. 2014. (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014).

@inproceedings{cec48fdc2758464780e8ea97050d30b7,

title = "EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease",

abstract = "Mild cognitive impairment (MCI) is a neurological condition that is ofte. The early stage of Alzheimer's disease (AD). This pilot study explores event-related multiscale entropy (MSE) measures as features for effectively discriminating between normal aging, MCI, and AD participants. Thirty two-channel scalp EEG records recorded during a working memory task from 43 age-matched participants (mean age 75.7 years)-17 normal controls (NC), 16 MCI, and 10 early ADare examined. Multiscale entropy curves are computed for responses durin. The working memory task. Support vector machine models are constructed to perform binary discriminations amon. The three groups. Leave-one-out cross-validation accuracies of 87.9% (p-value <1.322E-4) for MCI vs. NC, 88.9% (p-value <2.886E-5) for AD vs. NC, and 92.3% (p-value <4.910E-6) for MCI vs. AD are achieved. Results demonstrate links between event-related multiscale entropy dynamics of EEG and short-term memory deficits.",

keywords = "Alzheimer's disease, EEG, mild cognitive impairment, multiscale entropy",

author = "Joseph McBride and Xiaopeng Zhao and Nancy Munro and Gregory Jicha and Charles Smith and Yang Jiang",

note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014 ; Conference date: 06-05-2014 Through 08-05-2014",

year = "2014",

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day = "29",

doi = "10.1109/BSEC.2014.6867738",

language = "English",

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McBride, J, Zhao, X, Munro, N, Jicha, G, Smith, C & Jiang, Y 2014, EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease. in Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014., 6867738, Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014, 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations, BSEC 2014, Oak Ridge, United States, 5/6/14. https://doi.org/10.1109/BSEC.2014.6867738

EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease. / McBride, Joseph; Zhao, Xiaopeng; Munro, Nancy et al.
Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014. 2014. 6867738 (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease

AU - McBride, Joseph

AU - Zhao, Xiaopeng

AU - Munro, Nancy

AU - Jicha, Gregory

AU - Smith, Charles

AU - Jiang, Yang

PY - 2014/7/29

Y1 - 2014/7/29

N2 - Mild cognitive impairment (MCI) is a neurological condition that is ofte. The early stage of Alzheimer's disease (AD). This pilot study explores event-related multiscale entropy (MSE) measures as features for effectively discriminating between normal aging, MCI, and AD participants. Thirty two-channel scalp EEG records recorded during a working memory task from 43 age-matched participants (mean age 75.7 years)-17 normal controls (NC), 16 MCI, and 10 early ADare examined. Multiscale entropy curves are computed for responses durin. The working memory task. Support vector machine models are constructed to perform binary discriminations amon. The three groups. Leave-one-out cross-validation accuracies of 87.9% (p-value <1.322E-4) for MCI vs. NC, 88.9% (p-value <2.886E-5) for AD vs. NC, and 92.3% (p-value <4.910E-6) for MCI vs. AD are achieved. Results demonstrate links between event-related multiscale entropy dynamics of EEG and short-term memory deficits.

AB - Mild cognitive impairment (MCI) is a neurological condition that is ofte. The early stage of Alzheimer's disease (AD). This pilot study explores event-related multiscale entropy (MSE) measures as features for effectively discriminating between normal aging, MCI, and AD participants. Thirty two-channel scalp EEG records recorded during a working memory task from 43 age-matched participants (mean age 75.7 years)-17 normal controls (NC), 16 MCI, and 10 early ADare examined. Multiscale entropy curves are computed for responses durin. The working memory task. Support vector machine models are constructed to perform binary discriminations amon. The three groups. Leave-one-out cross-validation accuracies of 87.9% (p-value <1.322E-4) for MCI vs. NC, 88.9% (p-value <2.886E-5) for AD vs. NC, and 92.3% (p-value <4.910E-6) for MCI vs. AD are achieved. Results demonstrate links between event-related multiscale entropy dynamics of EEG and short-term memory deficits.

KW - Alzheimer's disease

KW - EEG

KW - mild cognitive impairment

KW - multiscale entropy

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M3 - Conference contribution

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T3 - Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014

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McBride J, Zhao X, Munro N, Jicha G, Smith C, Jiang Y. EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease. In Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014. 2014. 6867738. (Proceedings of the 2014 Biomedical Sciences and Engineering Conference - 5th Annual ORNL Biomedical Sciences and Engineering Conference: Collaborative Biomedical Innovations - The Multi-Scale Brain: Spanning Molecular, Cellular, Systems, Cognitive, Behavioral, and Clinical Neuroscience, BSEC 2014). doi: 10.1109/BSEC.2014.6867738

EEG multiscale entropy dynamics in mild cognitive impairment and early Alzheimer's disease

Abstract

Publication series

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Bibliographical note

Keywords

ASJC Scopus subject areas

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