Effect of 1, 25-vitamin D and parathyroidectomy on the uptake of aluminum in bone of rats with renal insufficiency

Excessive aluminum accumulation in bone is associated with abnormalities in bone formation and mineralization in man and animals. The factors that influence deposition of aluminum in bone are not well understood. In this study the influence of 1, 25-vitamin D on bone aluminum accumulation was evaluated in aluminum-loaded parathyroidectomized and nonparathyroidectomized rats with renal insufficiency. All groups of aluminum-loaded rats receiving 1, 25-vitamin D had less bone aluminum accumulation. This effect was not influenced by the presence or absence of parathyroid hormone. All rats administered 1, 25-vitamin D had elevated serum calcium and depressed serum phosphorus levels and lower body weight compared to controls. The results ascribe a potential role for 1, 25-vitamin D in the prevention of aluminum accumulation.