Effect of 6-hydroxydopamine or repeated amphetamine treatment on mesencephalic mRNA levels for AMPA glutamate receptor subunits in the rat

M. T. Bardo, P. M. Robinet, B. A. Mattingly, J. E. Margulies

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subunit mRNAs were assayed in the ventral mesencephalon of rats that received either a unilateral microinjection of the dopamine neurotoxin 6-hydroxydopamine (6-OHDA; Experiment 1) or repeated treatment with amphetamine (Experiment 2). GluR2 levels were decreased 1 and 3 days after the lesion, and GluR1 and GluR3 levels also showed a transient decrease at 1 day after the lesion. Repeated amphetamine treatment did not significantly alter GluR1-4 levels measured 30 min after the third or tenth amphetamine injection, even though locomotor sensitization was obtained. Thus, while the present results indicate that AMPA receptor subunits are associated with dopamine-containing cell bodies in the ventral mesencephalon, these transcripts may not be responsible for the development of amphetamine sensitization.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalNeuroscience Letters
Volume302
Issue number2-3
DOIs
StatePublished - Apr 20 2001

Bibliographical note

Funding Information:
Supported by USPHS grants DA05312, DA09687 and DA12964.

Keywords

  • 6-Hydroxydopamine
  • Amphetamine
  • Dopamine
  • Locomotor activity
  • Mesencephalon
  • Sensitization
  • α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor

ASJC Scopus subject areas

  • General Neuroscience

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