Effect of amphetamine on response inhibition in rats showing high or low response to novelty

M. T. Bardo, M. E. Cain, K. E. Bylica

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Previous work has shown that rats categorized as either high responder (HR) or low responder (LR) based on the amount of activity assessed in a novel environment show a differential response to stimulant reward, with HR rats self-administering more amphetamine and cocaine than LR rats. The current study assessed behavioral inhibitory processes in HR and LR rats using either fixed consecutive number (FCN) or differential reinforcement of low rate of responding (DRL) tasks. Individual differences in free-choice preference for a novel environment or novel object were also assessed to determine if these measures were predictive of performance on these inhibitory tasks. Results showed that, regardless of the test used to characterize individual differences in response to novelty, groups showed a similar ability to learn the FCN and DRL tasks. When subsequently pretreated with amphetamine, there was no significant difference between groups in performance efficiency (accuracy) on either the FCN or DRL task; however, based on activity in inescapable novelty, HR rats were less sensitive than LR rats to amphetamine-disrupted responding on the reinforcement lever in the FCN task. Although a deficit in inhibition is generally thought to play a role in drug abuse behavior, the differential rate of stimulant self-administration described previously between HR and LR rats more likely reflects an incentive motivational effect that is independent of response inhibition.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalPharmacology Biochemistry and Behavior
Issue number1
StatePublished - Sep 2006

Bibliographical note

Funding Information:
This study is supported by USPHS grants DA 05312 and DA16013.


  • Amphetamine
  • Differential reinforcement of low rate of responding (DRL)
  • Drug abuse
  • Fixed consecutive number (FCN)
  • Individual differences
  • Novelty

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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