TY - JOUR
T1 - Effect of antenatal zinc supplementation on impetigo in infants in Bangladesh
AU - Darmstadt, Gary L.
AU - Osendarp, Saskia J.M.
AU - Ahmed, Saifuddin
AU - Feldman, Candace
AU - Van Raaij, Joop M.A.
AU - Baqui, Abdullah H.
AU - Hautvast, J. G.A.J.
AU - Fuchs, George J.
PY - 2012/4
Y1 - 2012/4
N2 - We sought to determine the effects of maternal zinc supplementation on skin infections among infants in poor urban areas of Dhaka, Bangladesh. A double-blind, placebo-controlled, randomized trial was conducted among 199 and 221 Bangladeshi infants whose mothers were administered 30 mg daily of zinc or placebo, respectively. The mothers received zinc supplementation from 12-16 weeks' gestation until delivery, and the infants were followed up until 6 months of age. Among the infants of mothers who received zinc supplementation during the antenatal period, 10.6% had at least 1 episode of impetigo compared with 19.6% of the infants of mothers in the placebo group (P = 0.01). Infants in the treatment group had a 54% reduction in incidence rate of episodes of impetigo when compared with infants in the placebo group (P = 0.01). The effect of zinc supplementation was more pronounced among male infants (64% reduction) and intrauterine growth restricted and low birth weight infants (73% reduction) and among infants of mothers with increased parity (60% reduction) or decreased socioeconomic status (71% reduction).
AB - We sought to determine the effects of maternal zinc supplementation on skin infections among infants in poor urban areas of Dhaka, Bangladesh. A double-blind, placebo-controlled, randomized trial was conducted among 199 and 221 Bangladeshi infants whose mothers were administered 30 mg daily of zinc or placebo, respectively. The mothers received zinc supplementation from 12-16 weeks' gestation until delivery, and the infants were followed up until 6 months of age. Among the infants of mothers who received zinc supplementation during the antenatal period, 10.6% had at least 1 episode of impetigo compared with 19.6% of the infants of mothers in the placebo group (P = 0.01). Infants in the treatment group had a 54% reduction in incidence rate of episodes of impetigo when compared with infants in the placebo group (P = 0.01). The effect of zinc supplementation was more pronounced among male infants (64% reduction) and intrauterine growth restricted and low birth weight infants (73% reduction) and among infants of mothers with increased parity (60% reduction) or decreased socioeconomic status (71% reduction).
KW - acute lower respiratory infection
KW - impetigo
KW - infant
KW - morbidity
KW - photograph
KW - pneumonia
KW - skin infection
KW - supplementation
KW - zinc
UR - http://www.scopus.com/inward/record.url?scp=84858795196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858795196&partnerID=8YFLogxK
U2 - 10.1097/INF.0b013e318243e232
DO - 10.1097/INF.0b013e318243e232
M3 - Article
C2 - 22189527
AN - SCOPUS:84858795196
SN - 0891-3668
VL - 31
SP - 407
EP - 409
JO - Pediatric Infectious Disease Journal
JF - Pediatric Infectious Disease Journal
IS - 4
ER -
