Effect of antimalarials treatment on rat liver lysosomal function - An in vivo study

Samir P. Patel, Subhash D. Katewa, Surendra S. Katyare

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Effects of treatment in vivo with the antimalarials:chloroquine(CQ), primaquine (PQ) and quinine(Q) on lysosomal enzymes and lysosomal membrane integrity were examined. Treatment with the three antimalarials showed an apparent increase in the membrane stability. CQ treatment resulted in increase in both the 'free' and 'total' activities of all the enzymes i.e. acid phosphatase, RNase II, DNase II and cathepsin D. PQ treatment lowered the 'free' and 'total' activities of acid phosphatase and cathepsin D, but the DNase II activities increased. Treatment with Q resulted in increased 'free' and 'total' activities of RNase II and DNase II. While 'free' activities of acid phosphatase and cathepsin D were low; the 'total' activities increased significantly. Our results suggest that a generalized increase in free nucleases activities following prolonged treatment with antimalarials may lead to cell damage and / or necrosis.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalIndian Journal of Clinical Biochemistry
Volume20
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Acid phosphatase
  • Cathepsin D
  • DNase II
  • Lysosomal enzymes
  • Lysosomes
  • RNase II
  • T/F ratio

ASJC Scopus subject areas

  • Clinical Biochemistry

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