Effect of aortic regurgitation on the assessment of mitral valve orifice area by Doppler pressure half-time in mitral stenosis

Paul A. Grayburn, Mikel D. Smith, John C. Gurley, David C. Booth, Anthony N. DeMaria

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Evaluation of the severity of mitral stenosis by continuous-wave Doppler pressure half-time measurement is now well established. However, few data exist regarding the effect of aortic regurgitation (AR) on the validity of this method. Therefore, 73 patients were studied in whom cardiac catheterization and Doppler echocardiographic examinations were performed. Mitral valve orifice area was determined by the Gorlin equation, 2-dimensional echocardiography and Doppler pressure half-time. Doppler pressure half-time and catheterization estimates of mitral valve area correlated well (r = 0.85) in patients without significant mitral regurgitation. This correlation was maintained in patient subgroups with and without significant (at least 2+) AR (r = 0.86 and 0.83, respectively), Similarly, Doppler and 2-dimensional echocardiographic assessment of mitral valve area showed a strong correlation (r = 0.84). Again, the correlation between the 2 methods was similar in patients with and without significant AR (r = 0.86 and 0.82, respectively). Thus, Doppler pressure half-time estimates of mitral valve orifice area are accurate even in patients with AR.

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalAmerican Journal of Cardiology
Issue number4
StatePublished - Aug 1 1987

Bibliographical note

Funding Information:
From the Division of Cardiovascular Medicine, University Kentucky College of Medicine and Veterans Administration Medical Center, Lexington, Kentucky. This study was supported in part by a Fellowship Grant from the American Heart Association, Kentucky Affiliate, J.ouisville, Kentucky. Manuscript received January 2,1987: revised manuscript received and accepted March 16,1987. Address for reprints: Paul A. Grayburn, Cardiology, MN670, I Jniversity of Kentucky 800 Rose Street, Lexington, Kentucky 40536-0084.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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