TY - JOUR
T1 - Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice
AU - Bin, Xie Xiao
AU - Wolf, Katerina
AU - Schaffner, Thomas
AU - Malinverni, Raffaele
PY - 2000
Y1 - 2000
N2 - The effects of treatment with azithromycin plus rifampin (A+R), amoxicillin. (A), or placebo (P) on the chronic course of experimental Chlamydia pneumoniae pneumonitis in mice were assessed by culture, PCR, and immunocytochemistry as well as by degree of inflammation in lung tissue. Eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with A+R compared to after treatment with A or P. Combination therapy with azithromycin plus rifampin showed favorable effects in the chronic course of C. pneumoniae pneumonitis.
AB - The effects of treatment with azithromycin plus rifampin (A+R), amoxicillin. (A), or placebo (P) on the chronic course of experimental Chlamydia pneumoniae pneumonitis in mice were assessed by culture, PCR, and immunocytochemistry as well as by degree of inflammation in lung tissue. Eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with A+R compared to after treatment with A or P. Combination therapy with azithromycin plus rifampin showed favorable effects in the chronic course of C. pneumoniae pneumonitis.
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U2 - 10.1128/AAC.44.6.1761-1764.2000
DO - 10.1128/AAC.44.6.1761-1764.2000
M3 - Article
C2 - 10817751
AN - SCOPUS:0343362694
SN - 0066-4804
VL - 44
SP - 1761
EP - 1764
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 6
ER -
