Effect of chronic caffeine administration oh monoamine and monoamine metabolite concentratiows in rat brain

D. G. Kirch; T. B. Taylor; G. A. Gerhardt; N. L. Benowitz; C. Stephen; R. J. Wyatt

doi:10.1016/0028-3908(90)90073-Z

Effect of chronic caffeine administration oh monoamine and monoamine metabolite concentratiows in rat brain

D. G. Kirch, T. B. Taylor, G. A. Gerhardt, N. L. Benowitz, C. Stephen, R. J. Wyatt

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Caffeine was chronically administered in four doses (0, 10, 25, and 50 mg/kg/day) to rats via twice-daily intraperitoneal injections for 30 days. Concentrations of brain tissue monoamines, dopamine (DA), norepinephrine (NE), and serotonin (5HT), and monoamine metabolites, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5HIAA), were determined. At the 10 mg/kg/day dose, no significant changes were found compared with controls. At 25 mg/kg/day and 50 mg/kg/day significant changes were observed within each monoamine system. In striatum, DA and 5HT were increased, while DOPAC was decreased. In frontal cortex, NE was increased. In cerebellum, 5HT and MHPG were increased.

Original language	English
Pages (from-to)	599-602
Number of pages	4
Journal	Neuropharmacology
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/0028-3908(90)90073-Z
State	Published - Jun 1990

Bibliographical note

Funding Information:
The authors thank Tom Bryant, Diane Venable, and Jeffrey assistance and Sheila M. Johnson, Christina Wynn and Elaine manuscript. This work was supported in part by USPHS grants (N.L.B.).

Keywords

3-methoxy-4-hydroxyphenylglycol
caffeine
dihydroxyphenylacetic acid
dopamine
norepinephrine
serotonin

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(90)90073-Z

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title = "Effect of chronic caffeine administration oh monoamine and monoamine metabolite concentratiows in rat brain",

abstract = "Caffeine was chronically administered in four doses (0, 10, 25, and 50 mg/kg/day) to rats via twice-daily intraperitoneal injections for 30 days. Concentrations of brain tissue monoamines, dopamine (DA), norepinephrine (NE), and serotonin (5HT), and monoamine metabolites, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5HIAA), were determined. At the 10 mg/kg/day dose, no significant changes were found compared with controls. At 25 mg/kg/day and 50 mg/kg/day significant changes were observed within each monoamine system. In striatum, DA and 5HT were increased, while DOPAC was decreased. In frontal cortex, NE was increased. In cerebellum, 5HT and MHPG were increased.",

keywords = "3-methoxy-4-hydroxyphenylglycol, caffeine, dihydroxyphenylacetic acid, dopamine, norepinephrine, serotonin",

author = "Kirch, {D. G.} and Taylor, {T. B.} and Gerhardt, {G. A.} and Benowitz, {N. L.} and C. Stephen and Wyatt, {R. J.}",

note = "Funding Information: The authors thank Tom Bryant, Diane Venable, and Jeffrey assistance and Sheila M. Johnson, Christina Wynn and Elaine manuscript. This work was supported in part by USPHS grants (N.L.B.).",

year = "1990",

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doi = "10.1016/0028-3908(90)90073-Z",

language = "English",

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AU - Kirch, D. G.

AU - Taylor, T. B.

AU - Gerhardt, G. A.

AU - Benowitz, N. L.

AU - Stephen, C.

AU - Wyatt, R. J.

N1 - Funding Information: The authors thank Tom Bryant, Diane Venable, and Jeffrey assistance and Sheila M. Johnson, Christina Wynn and Elaine manuscript. This work was supported in part by USPHS grants (N.L.B.).

PY - 1990/6

Y1 - 1990/6

N2 - Caffeine was chronically administered in four doses (0, 10, 25, and 50 mg/kg/day) to rats via twice-daily intraperitoneal injections for 30 days. Concentrations of brain tissue monoamines, dopamine (DA), norepinephrine (NE), and serotonin (5HT), and monoamine metabolites, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5HIAA), were determined. At the 10 mg/kg/day dose, no significant changes were found compared with controls. At 25 mg/kg/day and 50 mg/kg/day significant changes were observed within each monoamine system. In striatum, DA and 5HT were increased, while DOPAC was decreased. In frontal cortex, NE was increased. In cerebellum, 5HT and MHPG were increased.

AB - Caffeine was chronically administered in four doses (0, 10, 25, and 50 mg/kg/day) to rats via twice-daily intraperitoneal injections for 30 days. Concentrations of brain tissue monoamines, dopamine (DA), norepinephrine (NE), and serotonin (5HT), and monoamine metabolites, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5HIAA), were determined. At the 10 mg/kg/day dose, no significant changes were found compared with controls. At 25 mg/kg/day and 50 mg/kg/day significant changes were observed within each monoamine system. In striatum, DA and 5HT were increased, while DOPAC was decreased. In frontal cortex, NE was increased. In cerebellum, 5HT and MHPG were increased.

KW - 3-methoxy-4-hydroxyphenylglycol

KW - caffeine

KW - dihydroxyphenylacetic acid

KW - dopamine

KW - norepinephrine

KW - serotonin

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Effect of chronic caffeine administration oh monoamine and monoamine metabolite concentratiows in rat brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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