Effect of chronic caffeine administration oh monoamine and monoamine metabolite concentratiows in rat brain

D. G. Kirch, T. B. Taylor, G. A. Gerhardt, N. L. Benowitz, C. Stephen, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Caffeine was chronically administered in four doses (0, 10, 25, and 50 mg/kg/day) to rats via twice-daily intraperitoneal injections for 30 days. Concentrations of brain tissue monoamines, dopamine (DA), norepinephrine (NE), and serotonin (5HT), and monoamine metabolites, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5HIAA), were determined. At the 10 mg/kg/day dose, no significant changes were found compared with controls. At 25 mg/kg/day and 50 mg/kg/day significant changes were observed within each monoamine system. In striatum, DA and 5HT were increased, while DOPAC was decreased. In frontal cortex, NE was increased. In cerebellum, 5HT and MHPG were increased.

Original languageEnglish
Pages (from-to)599-602
Number of pages4
JournalNeuropharmacology
Volume29
Issue number6
DOIs
StatePublished - Jun 1990

Bibliographical note

Funding Information:
The authors thank Tom Bryant, Diane Venable, and Jeffrey assistance and Sheila M. Johnson, Christina Wynn and Elaine manuscript. This work was supported in part by USPHS grants (N.L.B.).

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

Keywords

  • 3-methoxy-4-hydroxyphenylglycol
  • caffeine
  • dihydroxyphenylacetic acid
  • dopamine
  • norepinephrine
  • serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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