TY - JOUR
T1 - Effect of chronic low level manganese exposure on postural balance
T2 - A pilot study of residents in Southern Ohio
AU - Standridge, J. Shawn
AU - Bhattacharya, Amit
AU - Succop, Paul
AU - Cox, Cyndy
AU - Haynes, Erin
PY - 2008/12
Y1 - 2008/12
N2 - OBJECTIVE: The objective of this study was to determine the effect of non-occupational exposure to manganese (Mn) on postural balance. METHODS: Residents living near a ferromanganese refinery provided hair and blood samples after postural balance testing. The relationship between hair Mn and postural balance was analyzed with logistic regression. Following covariate adjustment, postural balance was compared with control data by analysis of covariance. RESULTS: Mean hair Mn was 4.4 μg/g. A significantly positive association was found between hair Mn and sway area (eyes open on the platform, P = 0.05; eyes closed on the platform, P = 0.04) and sway length (eyes open on the platform, P = 0.05; eyes closed on the platform, P = 0.04). Postural balance of residents was significantly larger than controls in 5 out of 8 postural balance outcomes. CONCLUSION: Preliminary findings suggest subclinical impairment in postural balance among residents chronically exposed to ambient Mn. A prospective study with a larger sample size is warranted.
AB - OBJECTIVE: The objective of this study was to determine the effect of non-occupational exposure to manganese (Mn) on postural balance. METHODS: Residents living near a ferromanganese refinery provided hair and blood samples after postural balance testing. The relationship between hair Mn and postural balance was analyzed with logistic regression. Following covariate adjustment, postural balance was compared with control data by analysis of covariance. RESULTS: Mean hair Mn was 4.4 μg/g. A significantly positive association was found between hair Mn and sway area (eyes open on the platform, P = 0.05; eyes closed on the platform, P = 0.04) and sway length (eyes open on the platform, P = 0.05; eyes closed on the platform, P = 0.04). Postural balance of residents was significantly larger than controls in 5 out of 8 postural balance outcomes. CONCLUSION: Preliminary findings suggest subclinical impairment in postural balance among residents chronically exposed to ambient Mn. A prospective study with a larger sample size is warranted.
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U2 - 10.1097/JOM.0b013e3181896936
DO - 10.1097/JOM.0b013e3181896936
M3 - Article
C2 - 19092498
AN - SCOPUS:65849270077
SN - 1076-2752
VL - 50
SP - 1421
EP - 1429
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 12
ER -
