TY - JOUR
T1 - Effect of Coccinia indica leaf extract on plasma antioxidants in Streptozotocin-induced experimental diabetes in rats
AU - Venkateswaran, S.
AU - Pari, L.
PY - 2003/6
Y1 - 2003/6
N2 - The present study was carried out to investigate the antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic Medicine in India, in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in plasma thiobarbituric acid reactive substances, hydroperoxides, vitamin E and ceruloplasmin. The extract also caused a significant increase in plasma vitamin C and reduced glutathione, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.
AB - The present study was carried out to investigate the antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic Medicine in India, in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in plasma thiobarbituric acid reactive substances, hydroperoxides, vitamin E and ceruloplasmin. The extract also caused a significant increase in plasma vitamin C and reduced glutathione, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.
KW - Antioxidants
KW - Coccinia indica
KW - Ethanolic extract
KW - Streptozotocin diabetes
UR - http://www.scopus.com/inward/record.url?scp=0012507120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0012507120&partnerID=8YFLogxK
U2 - 10.1002/ptr.1195
DO - 10.1002/ptr.1195
M3 - Article
C2 - 12820225
AN - SCOPUS:0012507120
SN - 0951-418X
VL - 17
SP - 605
EP - 608
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 6
ER -
