The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in liver and kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.
|Number of pages||6|
|Journal||Journal of Ethnopharmacology|
|State||Published - Feb 2003|
Bibliographical noteFunding Information:
The financial assistance from ICMR, New Delhi in the form of SRF to the author S. Venkateswaran is gratefully acknowledged.
- Coccinia indica
- Enzymic antioxidants
- Ethanolic extract
- Streptozotocin diabetes
ASJC Scopus subject areas
- Drug Discovery