Abstract
The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in liver and kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.
| Original language | English |
|---|---|
| Pages (from-to) | 163-168 |
| Number of pages | 6 |
| Journal | Journal of Ethnopharmacology |
| Volume | 84 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Feb 2003 |
Bibliographical note
Funding Information:The financial assistance from ICMR, New Delhi in the form of SRF to the author S. Venkateswaran is gratefully acknowledged.
Keywords
- Coccinia indica
- Enzymic antioxidants
- Ethanolic extract
- Streptozotocin diabetes
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
