Abstract
The antioxidant effect of an ethanolic extract of Coccinia indica leaves, an indigenous plant used in Ayurvedic medicine in India, was studied in Streptozotocin-diabetic rats. Oral administration of Coccinia indica leaf extract (CLEt) (200 mg/kg body weight) for 45 days resulted in a significant reduction in thiobarbituric acid reactive substances and hydroperoxides. The extract also causes a significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase in liver and kidney of streptozotocin diabetic rats, which clearly shows the antioxidant property of CLEt. The effect of CLEt at 200 mg/kg body weight was more effective than glibenclamide.
| Original language | English |
|---|---|
| Pages (from-to) | 163-168 |
| Number of pages | 6 |
| Journal | Journal of Ethnopharmacology |
| Volume | 84 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Feb 2003 |
Bibliographical note
Funding Information:The financial assistance from ICMR, New Delhi in the form of SRF to the author S. Venkateswaran is gratefully acknowledged.
Funding
The financial assistance from ICMR, New Delhi in the form of SRF to the author S. Venkateswaran is gratefully acknowledged.
| Funders | Funder number |
|---|---|
| Indian Council of Medical Research |
Keywords
- Coccinia indica
- Enzymic antioxidants
- Ethanolic extract
- Streptozotocin diabetes
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
