Effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracene-induced, two stage mouse skin carcinogenesis

H. P. Glauert, M. R. Bennink

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The effect of deoxycholic acid on 7,12-dimethylbenz(a)anthracene croton oil carcinogenesis in mouse skin was tested. Painting deoxycholic acid in addition to croton oil during promotion resulted in the earlier appearance of tumors, a greater tumor incidence, and a larger number of tumors per animal. DMBA initiation followed by either deoxycholic acid or solvents during the promotion period produced no tumors. Animals receiving deoxycholic acid or solvents alone developed no tumors.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume22
Issue number3
StatePublished - 1978

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics (all)

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