Abstract
The peroxisome proliferators Wy-14,643, BR-931, nafenopin and ciprofibrate were tested in the primary hepatocyte culture-unscheduled DNA synthesis assay and in the Ames Salmonella microsome mutagenicity assay. The amount of unscheduled DNA synthesis (UDS) in hepatocytes was determined by quantifying the amount of [3H] thymidine incorporated into DNA in the presence of hydroxyurea after isolation of nuclei from hepatocytes treated with the test agent. Wy-14,643 and BR-931 induced unscheduled DNA synthesis in rat hepatocytes, whereas nafenopin and ciprofibrate had no effect. All of the peroxisome proliferators were negative in the Ames Salmonella assay.
| Original language | English |
|---|---|
| Pages (from-to) | 147-156 |
| Number of pages | 10 |
| Journal | Cancer Letters |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 1984 |
Bibliographical note
Funding Information:This work was supported by DHHS PHS National Research Service Award 5 T32 ES07015 from the National Institute of Environmental Health Sciences, Grants CA-07175 and CA-22484 from the National Cancer Institute, and Grant GM-23750 from the National Institutes of Health.
Funding
This work was supported by DHHS PHS National Research Service Award 5 T32 ES07015 from the National Institute of Environmental Health Sciences, Grants CA-07175 and CA-22484 from the National Cancer Institute, and Grant GM-23750 from the National Institutes of Health.
| Funders | Funder number |
|---|---|
| National Institutes of Health (NIH) | |
| U.S. Department of Health and Human Services | 5 T32 ES07015 |
| National Childhood Cancer Registry – National Cancer Institute | P30CA007175, GM-23750 |
| National Institute of Environmental Health Sciences (NIEHS) | CA-22484 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
