TY - JOUR
T1 - EFFECT OF P‐CHLOROPHENYLALANINE ON BRAIN MONOAMINES AND BEHAVIOUR DURING ETHANOL WITHDRAWAL IN MICE
AU - GRIFFITHS, P. J.
AU - LITTLETON, J. M.
AU - ORTIZ, A.
PY - 1974/6
Y1 - 1974/6
N2 - The administration of p‐chlorophenylalanine to mice prevents the rise in brain 5‐hydroxytryptamine concentration associated with ethanol withdrawal but does not affect the increase in brain catecholamines which occurs at the same time. The locomotor excitement, piloerection, tremor and handling convulsions which occur during ethanol withdrawal were not affected. These results suggest that the increase in brain 5‐hydroxytryptamine which occurs in ethanol withdrawal is a consequence of increased 5‐hydroxytryptamine synthesis and that it is probably not involved in the above behavioural changes of ethanol withdrawal. 1974 British Pharmacological Society
AB - The administration of p‐chlorophenylalanine to mice prevents the rise in brain 5‐hydroxytryptamine concentration associated with ethanol withdrawal but does not affect the increase in brain catecholamines which occurs at the same time. The locomotor excitement, piloerection, tremor and handling convulsions which occur during ethanol withdrawal were not affected. These results suggest that the increase in brain 5‐hydroxytryptamine which occurs in ethanol withdrawal is a consequence of increased 5‐hydroxytryptamine synthesis and that it is probably not involved in the above behavioural changes of ethanol withdrawal. 1974 British Pharmacological Society
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U2 - 10.1111/j.1476-5381.1974.tb09662.x
DO - 10.1111/j.1476-5381.1974.tb09662.x
M3 - Article
C2 - 4281335
AN - SCOPUS:0016238896
SN - 0007-1188
VL - 51
SP - 307
EP - 309
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
IS - 2
ER -