Effect of propofol on the incidence of postoperative vomiting after strabismus surgery in pediatric outpatients

M. F. Watcha, R. M. Simeon, P. F. White, J. L. Stevens

Research output: Contribution to journalArticlepeer-review

201 Scopus citations


Vomiting is a common problem after strabismus surgery in pediatric outpatients. We compared the effects of propofol with and without N2O and droperidol to the effects of a conventional regimen consisting of halothane-N2O-droperidol on the recovery characteristics and the incidence of postoperative emesis after strabismus surgery in 120 ASA physical status 1 or 2 children. After induction of anesthesia with halothane-N2O, patients were randomly assigned to one of four groups. Group A (control) received halothane, 66% N2O, and droperidol 75 μg·kg-1; group B, propofol 2 mg·kg-1 bolus followed by infusion of 160 μg·kg-1·min-1; group C, propofol (as in group B) and 66% N2O; and group D, propofol (as in group B), 66% N2O (as in group C), and droperidol 75 μg·kg-1. Patients in group B had more episodes of intraoperative oculocardiac reflex responses than patients in group A, but had shorter times to extubation, oral intake, ambulation, and discharge, as well as a lower incidence of postoperative emesis (P < 0.05). The addition of N2O to the propofol anesthetic regimen (group C) was associated with an increased incidence of emesis (P < 0.05), whereas the addition of droperidol to the propofol-N2O regimen (group D) did not affect the incidence of emesis compared to the other three groups. We conclude that maintenance of anesthesia with a total intravenous regimen using propofol results in a more rapid recovery and less postoperative emesis than with a halothane-N2O-droperidol regimen.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
Issue number2
StatePublished - 1991


  • Anesthesia: pediatrics
  • Anesthetic technique: continuous infusion; inhalational
  • Anesthetics, gases: nitrous oxide
  • Anesthetics, intravenous: propofol
  • Anesthetics, volatile: halothane
  • Antiemetics: droperidol
  • Complications: postoperative vomiting
  • Surgery: strabismus

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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