Abstract
Recombinant tumor necrosis factor (rTNF) has been shown to protect mice against lethal bacterial infections. We previously reported that in in vitro experiments with mouse peritoneal macrophages, rTNF inhibited intracellular multiplication of Trypanosoma cruzi but not of Toxoplasma gondii. These disparate results led us to study the effect of rTNF on the in vivo infection with these parasites. Daily administration of 0.5 and 5.0 μg rTNF resulted in a dose-dependent, significantly decreased time to death (p < 0.05) in mice infected with lethal doses of T. cruzi. The same effect was found in mice infected with T. gondii and given a daily dose of 5.0 μg rTNF. Lower doses of rTNF did not significantly affect time to death of mice infected with either parasite.
| Original language | English |
|---|---|
| Pages (from-to) | 570-574 |
| Number of pages | 5 |
| Journal | Immunology |
| Volume | 68 |
| Issue number | 4 |
| State | Published - 1989 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology