Abstract
Aim: To examine the function of the four constituent medicines of Si-Ni-San(Composition of Radix Bupleuri, Radix Paeoniae alba, Fructus Aurantii immaturus and Radix Glycyrrhizae) and each single drug on alleviating experimental liver injury. Method: Hepatocyte damage induced by CCl4 and PCl-DTH, Con A-induce lymphocyte proliferation, LPS-induced NO production in macrophage and gelatin zymography assay were used. Result: The results show that the activities of Si-Ni-San were stronger than those of each constituent. Among the four constituent medicines, Radix Bupleuri mainly affected the main process of liver injury through protecting hepatocyte membrane and enhancing NO, a protective factor, production in macrophages; Radix Paeoniae alba mainly affected immune cells through inhibiting the activation, migration and infiltration of lymphocytes, and inducing the dysfunction of liver-infiltrating cells; Radix Glycyrrhizae had both hepatoprotective and immunomodulatory activities contributing to SNS alleviating liver injury. Conclusion: Each constituent of Si-Ni-San affects the different target of liver injury and their comprehensive effect resulted in the stronger effect of the prescription.
Original language | English |
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Pages (from-to) | 45-49 |
Number of pages | 5 |
Journal | Chinese Journal of Natural Medicines |
Volume | 2 |
Issue number | 1 |
State | Published - Jan 2004 |
Keywords
- Experimental liver injury
- Hepatocyte
- Immuno-modulation
- Si-Ni-San
ASJC Scopus subject areas
- Drug Discovery
- Complementary and alternative medicine