Effect of Si-Ni-San and its individual component drugs on experimental liver injury

Jie Yun Jiang, Qiang Xu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Aim: To examine the function of the four constituent medicines of Si-Ni-San(Composition of Radix Bupleuri, Radix Paeoniae alba, Fructus Aurantii immaturus and Radix Glycyrrhizae) and each single drug on alleviating experimental liver injury. Method: Hepatocyte damage induced by CCl4 and PCl-DTH, Con A-induce lymphocyte proliferation, LPS-induced NO production in macrophage and gelatin zymography assay were used. Result: The results show that the activities of Si-Ni-San were stronger than those of each constituent. Among the four constituent medicines, Radix Bupleuri mainly affected the main process of liver injury through protecting hepatocyte membrane and enhancing NO, a protective factor, production in macrophages; Radix Paeoniae alba mainly affected immune cells through inhibiting the activation, migration and infiltration of lymphocytes, and inducing the dysfunction of liver-infiltrating cells; Radix Glycyrrhizae had both hepatoprotective and immunomodulatory activities contributing to SNS alleviating liver injury. Conclusion: Each constituent of Si-Ni-San affects the different target of liver injury and their comprehensive effect resulted in the stronger effect of the prescription.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalChinese Journal of Natural Medicines
Issue number1
StatePublished - Jan 2004


  • Experimental liver injury
  • Hepatocyte
  • Immuno-modulation
  • Si-Ni-San

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine


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