Effect of taurine depletion on angiotensin II-mediated modulation of myocardial function

Stephen W. Schaffer, Cherry Ballard-Croft, Kyoko Takahashi, Junichi Azuma

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6 Scopus citations


Taurine depletion was induced by either incubation of isolated myocytes with 5 mM β-alanine or feeding rats with water containing 3% β-alanine. Hearts of taurine depleted rats exhibited an impairment in myocardial relaxation, associated with a decrease in Na+- Ca2+ exchanger activity. Exposure of the heart to angiotensin II, an activator of the Na+- Ca2+ exchanger, eliminated the relaxation defect. In agreement with the contractile results, taurine depletion prolonged the calcium transient, an effect which was partially eliminated by exposure to angiotensin II. Although peak systolic [Ca2+](i) was modestly depressed in the taurine depleted myocyte, peak ventricular pressure was normal. This may be related to an elevation in pH, induced by taurine depletion. Angiotensin II had little effect on contractility of the taurine depleted heart, presumably because of two opposing effects, a reduction in pH(i) and an increase in [Ca2+](i). Thus, taurine depletion alters contractile function and ion transport and both of these effects are modulated by exposure of the heart to angiotensin II.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1998

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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