Effect of two corticotomy protocols on periodontal tissue and orthodontic movement

Marcelo Lelis Zuppardo, Milton Santamaria, Camila Lopes Ferreira, Mariéllen Longo, Joni Augusto Cirelli, Mauro Pedrine Santamaria, Maria Aparecida Neves Jardini

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: To compare two corticotomy surgical protocols in rats to verify whether they alter conventional orthodontic movement. Methodology: Sixty Wistar rats were divided into three groups – orthodontic movement (CG), orthodontic movement and corticotomy (G1) and orthodontic movement with corticotomy and decortication (G2) – and euthanized after 7 and 14 days. Tooth movement (mm), bone volume fraction and bone volume ratio to total volume (BV/TV), and bone mineral density (BMD) were evaluated by micro-CT. The total amount of bone was measured in square millimeters and expressed as the percentage of bone area in the histomorphometry. The number of positive TRAP cells and RANK/RANKL/OPG interaction were also investigated. Results: Day 14 showed a statistically significant difference in orthodontic tooth movement in CG compared with G1 (7.52 mm; p=0.009) and G2 (7.36 mm; p=0.016). A micro-CT analysis revealed a difference between CG, G1 and G2 regarding BV/TV, with G1 and G2 presenting a lower BV/TV ratio at 14 days (0.77 and 0.73 respectively); we found no statistically significant differences regarding BMD. There was a difference in the total amount of bone in the CG group between 7 and 14 days. At 14 days, CG presented a significantly higher bone percentage than G1 and G2. Regarding TRAP, G2 had more positive cells at 7 and 14 days compared with CG and G1. Conclusion: Corticotomy accelerates orthodontic movement. Decortication does not improve corticotomy efficiency.

Original languageEnglish
Article numbere20190766
Pages (from-to)1-10
Number of pages10
JournalJournal of Applied Oral Science
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020, Bauru School of Dentistry, University of Sao Paulo. All rights reserved.


  • Animal study
  • Corticotomy
  • Orthodontic movement

ASJC Scopus subject areas

  • General Dentistry


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