TY - JOUR
T1 - Effect of two gold compounds on human polymorphonuclear leukocyte lysosomal function and phagocytosis
AU - Kühn, Stephanus H.
AU - Gemperli, M. Beatrice
AU - De Beer, Frederick C.
PY - 1985/3
Y1 - 1985/3
N2 - Lysosomal neutral proteases, once released, are considered to play an important role in the rheumatoid inflammatory process. The effect of two gold compounds on human polymorphonuclear lysosomal enzymes was studied during reverse endocytosis. Phagocytosis was assessed using dual-labeled liposomes. Auranofin, a new antirheumatic gold compound, reduces human polymorphonuclear leukocyte phagocytoses and lysosomal elastase and β-glucuronidase release at a therapeutically achievable concentration (5 μM), Sodium aurothiomalate was ineffective at this concentration.
AB - Lysosomal neutral proteases, once released, are considered to play an important role in the rheumatoid inflammatory process. The effect of two gold compounds on human polymorphonuclear lysosomal enzymes was studied during reverse endocytosis. Phagocytosis was assessed using dual-labeled liposomes. Auranofin, a new antirheumatic gold compound, reduces human polymorphonuclear leukocyte phagocytoses and lysosomal elastase and β-glucuronidase release at a therapeutically achievable concentration (5 μM), Sodium aurothiomalate was ineffective at this concentration.
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U2 - 10.1007/BF00915410
DO - 10.1007/BF00915410
M3 - Article
C2 - 3920144
AN - SCOPUS:0021906983
VL - 9
SP - 39
EP - 44
IS - 1
ER -