Effect of two gold compounds on human polymorphonuclear leukocyte lysosomal function and phagocytosis

Stephanus H. Kühn, M. Beatrice Gemperli, Frederick C. De Beer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Lysosomal neutral proteases, once released, are considered to play an important role in the rheumatoid inflammatory process. The effect of two gold compounds on human polymorphonuclear lysosomal enzymes was studied during reverse endocytosis. Phagocytosis was assessed using dual-labeled liposomes. Auranofin, a new antirheumatic gold compound, reduces human polymorphonuclear leukocyte phagocytoses and lysosomal elastase and β-glucuronidase release at a therapeutically achievable concentration (5 μM), Sodium aurothiomalate was ineffective at this concentration.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalInflammation
Volume9
Issue number1
DOIs
StatePublished - Mar 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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