Effect of Vigilance Changes on the Incidence of High Frequency Oscillations in the Epileptic Brain

Amir F. Al-Bakri, Farid Yaghouby, Walter Besio, Lei Ding, Pradeep Modur, Sridhar Sunderam

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Recent studies show that the rate of cortical high frequency oscillations (HFOs) differentiates epileptogenic tissue in individuals with epilepsy. However, HFO occurrence can vary widely with vigilance state. In this study we attempt to characterize this variation, which has implications for the choice of a suitable diagnostic baseline for spatiotemporal analysis of HFO activity. We analyzed simultaneous recordings of the scalp electroencephalogram (EEG) and the electrocorticogram (ECoG) to examine the correlation of HFO activity with vigilance state. We detected HFOs (80-500 Hz) from all bipolar ECoG derivations using the well-known Staba algorithm in ten seizure-free overnight recordings from five patients being evaluated for surgery. In addition, we classified EEG features using a linkage tree into four vigilance states representing gradations in sleep depth from wakefulness to slow wave sleep. Finally, we examined the correlation between vigilance state and HFO occurrence in the five channels with the most HFOs in each recording. The proportion of 30-s epochs containing HFOs was found to increase significantly with sleep depth (p<0.01). Further analysis is necessary to examine the effects of epoch length and sample size in the choice of diagnostic baseline.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Pages991-994
Number of pages4
ISBN (Electronic)9781538636466
DOIs
StatePublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume2018-July
ISSN (Print)1557-170X

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Country/TerritoryUnited States
CityHonolulu
Period7/18/187/21/18

Bibliographical note

Funding Information:
Supported in part by National Science Foundation Grant No. 1539068. Al-Bakri received scholarship support from the University of Babylon, Iraq.

Publisher Copyright:
© 2018 IEEE.

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Fingerprint

Dive into the research topics of 'Effect of Vigilance Changes on the Incidence of High Frequency Oscillations in the Epileptic Brain'. Together they form a unique fingerprint.

Cite this