Effect of vitamin a administration on response to oral pollo vaccination

Mohammad M. Rahman, Jose O. Alvarez, Dilip Mahalanabis, Mohammad A. Wahed, Mohammad A. Islam, Leanne Unicomb, Demissie Habte, George J. Fuchs

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


To evaluate the effect of simultaneous administration of vitamin A and Oral Polio Vaccine (OPV) on seroconversion to OPV a randomized doubleblind, placebo-controlled trial was conducted. Fifty-seven infants were randomly given either 50,000 I.U. vitamin A (n=34) or placebo (n=23) with each OPV vaccine at monthly intervals. Seroconversion to polio were 81% (79% in vitamin A group and 83% in placebo group, p=0.76) for polio virus type 1, 86% (82% in vitamin A group and 91% in placebo group, p=0.34) for polio virus type 2, and 84% (82% in vitamin A group and 87% in placebo group, p=0.64) for polio virus type 3. A multiple logistic regression model was done to examine the factors associated with reduced seroconversion (polio virus type 1). For adequate vitamin A status the adjusted odds ratio of seroconversion was 0.24 (95% CI: 0.04-1.49, p=0. 11) and that for high maternal antibody was 0.11 (95% CI: 0.02-0.68, p=0.015). The geometric mean titer (GMT) was significantly lower in infants with adequate vitamin A stores compared to vitamin A deficient infants (p=0.04; Mann-Whitney test). The results of this study suggest that vitamin A supplementation had no effect on seroconversion, however, in children with adequate vitamin A status there was a trend towards lower seroconversion. High maternal antibody was significantly associated with reduced seroconversion to the oral polio vaccine.

Original languageEnglish
Pages (from-to)1125-1133
Number of pages9
JournalNutrition Research
Issue number7
StatePublished - Jul 1998

Bibliographical note

Funding Information:
The research was supported by United States Agency for International Development (USAID) under grant no. DPE-5986-A-1009-00, with the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), the John J. Sparkman Center for International Public Health Education at the University of Alabama at Birmingham and the ACME Laboratories, Bangladesh.

Funding Information:
The ICDDR,B is supported by the aid agencies of the Governments of Australia, Bangladesh, Belgium, Canada, Denmark, Germany, Japan, the Netherlands, Norway, Saudi Arabia, Sri Lanka, Sweden, Switzerland, Thailand, the United Kingdom and the United States; international organizations including Arab Gulf Fund, Asian Development Bank, European Union, the United Nations Children’s Fund (UNICEF), the United Nations Development Programme (UNDP), the United Nations Population Fund (UNFPA) and the World Health Organization (WHO): private foundations including Aga Khan Foundation, Child Health Foundation (CHF), Ford Foundation, Population Council, Rockefeller Foundation and the Sasakawa Foundation: and private organizations including American Express Bank, Bayer A.G., CARE, Family Health International, Helen Keller International, the Johns Hopkins University, Macro International, New England Medical Centre. Procter Gamble, RAND Corporation, SANDOZ, Swiss Red Cross and the University of Alabama at Birmingham, the University of Iowa, and others.


  • Infants
  • Polio Vaccination
  • Seroconversion
  • Vitamin A

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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